Influence of Recombination on Development of Mutational Resistance to Linezolid in Enterococcus faecalis JH2-2

被引：14

作者：

Boumghar-Bourtchai, Leyla ^{[1
]}

Dhalluin, Anne ^{[1
,3
]}

Malbruny, Brigitte ^{[1
,2
]}

Galopin, Sebastien ^{[1
]}

Leclercq, Roland ^{[1
,2
]}

机构：

[1] Univ Caen, EA Interact Hote & Microorganismes Epitheliums 21, F-14032 Caen, France

[2] CHU Cote Nacre, Microbiol Serv, Caen, France

[3] Univ Caen, UFR Sci Pharmaceut, F-14032 Caen, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 09期

关键词：

RIBOSOMAL-RNA; TARGET; SITE;

D O I：

10.1128/AAC.01633-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We compared the propensities of Enterococcus faecalis JH2-2 and of the recombination-deficient JH2-2 recA strain to develop mutational resistance to linezolid. In both organisms, a mutation in a single rrl copy conferred resistance to linezolid. Delay in acquisition of the mutation by other rrl copies in JH2-2 recA showed that gene conversion contributed to the acquisition of resistance.

引用

页码：4007 / 4009

页数：3