Diuretic and nephroprotective effect of Jawarish Zarooni Sada - a polyherbal unani formulation

被引：20

作者：

Afzal, M ^{[1
]}

Khan, NA ^{[1
]}

Ghufran, A ^{[1
]}

Iqbal, A ^{[1
]}

Inamuddin, M ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Fac Unani Med, Dept Ilmul Advia, Aligarh 202002, Uttar Pradesh, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2004年 / 91卷 / 2-3期

关键词：

diuretic; nephroprotective; nephrotoxicity; Unani medicine;

D O I：

10.1016/j.jep.2003.12.029

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A number of drugs, both single and compound preparations are used widely in Tibb-e-Unani (Unani medicine) in the management of renal diseases. But such drugs mostly, have not been investigated for their described effects. Jawarish Zarooni Sada (JZS) is one Such polyherbal preparation containing 15 ingredients, mainly described to be diuretic and nephroprotective. Therefore, in the present study ethanol and water extracts of JZS (300 mg each) were investigated for diuretic activity by measuring the total Urine Output over a period of 6 h. Sodium and potassium level in Urine sample was also estimated. Nephroprotective activity of JZS against gentamicin-induced nephrotoxicity was investigated by administering JZS along with high dose of gentamicin (40 mg/kg) and elevation of serum Urea and serum creatinine was taken as the index of nephrotoxicity. JZS showed significant diuretic and nephroprotective effect. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：219 / 223

页数：5

共 25 条

[1]

AFZAL M, 2003, PHYSICOTHERMAL STAND, V46, P75

[2]

Ali B. H., 2001, Indian Journal of Pharmacology, V33, P369

[3]

AMIN KMY, 1994, 4 INT C ETHN LUCKN N, P94

[4]

ANWAR S, 1999, EFFECTS BANADIQAL BU, V42, P31

[5] AMINOGLYCOSIDE ACCUMULATION KINETICS IN RAT RENAL PARENCHYMA [J].

ARONOFF, GR ;

POTTRATZ, ST ;

BRIER, ME ;

WALKER, NE ;

FINEBERG, NS ;

GLANT, MD ;

LUFT, FC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 23 (01) :74-78

[6]

AZHAR M, 2000, THESIS FM JAMIA HAMD

[7] SEX-RELATED DIFFERENCES IN THE SUSCEPTIBILITY OF RATS TO GENTAMICIN-NEPHROTOXICITY [J].

BENNETT, WM ;

PARKER, RA ;

ELLIOTT, WC ;

GILBERT, DN ;

HOUGHTON, DC .

JOURNAL OF INFECTIOUS DISEASES, 1982, 145 (03) :370-373

[8] HEPATOPROTECTIVE ACTIVITY OF CARROT (DAUCUS-CAROTA L) AGAINST CARBON-TETRACHLORIDE INTOXICATION IN MOUSE-LIVER [J].

BISHAYEE, A ;

SARKAR, A ;

CHATTERJEE, M .

JOURNAL OF ETHNOPHARMACOLOGY, 1995, 47 (02) :69-74

[9]

Freirich EJ, 1968, CANC CHEMOTHERAPY RE, V50, P219

[10]

Gilman GA, 1992, PHARMACOL BASIS THER, V2, P1106

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