Synthesis, characterization and biocompatibility studies on chitosan-graft-poly(EGDMA)

被引：30

作者：

Adali, Terin ^{[1
]}

Yilmaz, Elvan ^{[2
]}

机构：

[1] Near East Univ, Dept Biomed Engn, Lefkosa TRNC, Mersin, Turkey

[2] Eastern Mediterranean Univ, Dept Chem, Gazimagusa TRNC, Mersin, Turkey

来源：

CARBOHYDRATE POLYMERS | 2009年 / 77卷 / 01期

关键词：

Biocompatibility; Biodegradability; Cerium(IV); Copolymerization; Dimethacrylate; CHITOSAN;

D O I：

10.1016/j.carbpol.2008.12.017

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Poly(ethylene glycol dimethacrylate), poly(EGDMA), was grafted onto chitosan by using a redox initiation system. Chitosan-graft-poly(EGDMA) products were characterized by DSC, TGA, FTIR and XRD techniques. Chitosan-graft-poly(EGDMA) was found to be enzymatically degradable in aqueous solutions of lysozyme, lipase and a mixture of a-amylase and protease. The biocompatibility of chitosan-graft-poly (EGDMA) with 871% grafting yield was investigated by studying its cytotoxicity, sensitization, irritation, acute systemic toxicity and hemolytic activity. The results of biocompatibility experiments showed that the product can potentially be used for external intervention devices on bone and other tissue. (C) 2009 Published by Elsevier Ltd.

引用

页码：136 / 141

页数：6

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