Antioxidant defense and aging in C. elegans Is the oxidative damage theory of aging wrong?

被引：210

作者：

Gems, David

Doonan, Ryan

机构：

[1] UCL, Res Dept Genet, London WC1E 6BT, England

[2] UCL, Inst Healthy Ageing, London WC1E 6BT, England

来源：

CELL CYCLE | 2009年 / 8卷 / 11期

基金：

英国惠康基金;

关键词：

aging; antioxidant; C; elegans; catalase; free radical; nematode; oxidative stress; ROS; superoxide dismutase; theory; SUPEROXIDE-DISMUTASE GENE; LIFE-SPAN; CAENORHABDITIS-ELEGANS; STRESS RESISTANCE; METABOLIC-RATE; EXPRESSION; EXTENSION; LONGEVITY; OVEREXPRESSION; LONG;

D O I：

10.4161/cc.8.11.8595

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The oxidative damage theory of aging once seemed almost proven. Yet recently the buzzards have been assembling in the blue skies above it. New challenges to the theory from work using nematode worms seem set to bring them down to peck at its bones. But is the theory really dead, or does it just need to be modified?

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页码：1681 / 1687

页数：7

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