Loci at chromosomes 13, 19 and 20 influence age at natural menopause

被引：132

作者：

Stolk, Lisette ^{[1
,2
,3
]}

Zhai, Guangju ^{[4
]}

van Meurs, Joyce B. J. ^{[1
,3
]}

Verbiest, Michael M. P. J. ^{[1
]}

Visser, Jenny A. ^{[1
]}

Estrada, Karol ^{[1
]}

Rivadeneira, Fernando ^{[1
,2
]}

Williams, Frances M. ^{[4
]}

Cherkas, Lynn ^{[4
]}

Deloukas, Panos

Soranzo, Nicole ^{[5
]}

de Keyzer, Jules J. ^{[6
]}

Pop, Victor J. M. ^{[7
]}

Lips, Paul ^{[8
]}

Lebrun, Corinne E. I. ^{[1
,9
]}

van der Schouw, Yvonne T. ^{[9
]}

Grobbee, Diederick E. ^{[9
]}

Witteman, Jacqueline ^{[2
,3
]}

Hofman, Albert ^{[2
,3
]}

Pols, Huibert A. P. ^{[1
]}

Laven, Joop S. E. ^{[10
]}

Spector, Tim D. ^{[4
]}

Uitterlinden, Andre G. ^{[1
,3
]}

机构：

[1] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[2] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[3] NGI NCHA, Rotterdam, Netherlands

[4] Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England

[5] Wellcome Trust Sanger Inst, Hinxton, England

[6] Ctr Diagnost Eindhoven, Res Unit, Eindhoven, Netherlands

[7] Tilburg Univ, Dept Clin & Hlth Psychol, NL-5000 LE Tilburg, Netherlands

[8] Vrije Univ Amsterdam, Med Ctr, Endocrine Sect, Dept Internal Med, Amsterdam, Netherlands

[9] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[10] Erasmus MC, Dept Obstet & Gynaecol, Rotterdam, Netherlands

来源：

NATURE GENETICS | 2009年 / 41卷 / 06期

基金：

英国惠康基金;

关键词：

ASSOCIATION; HERITABILITY;

D O I：

10.1038/ng.387

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 x 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 x 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 x 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

引用

页码：645 / 647

页数：3

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