Molecularly imprinted polymers for drug delivery

被引:320
作者
Alvarez-Lorenzo, C [1 ]
Concheiro, A [1 ]
机构
[1] Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela, Spain
来源
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2004年 / 804卷 / 01期
关键词
drug delivery; molecularly imprinted polymers;
D O I
10.1016/j.jchromb.2003.12.032
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Molecular imprinting technology has an enormous potential for creating satisfactory drug dosage forms. Although its application in this field is just at an incipient stage, the use of MIPs in the design of new drug delivery systems (DDS) and devices useful in closely related fields, such as diagnostic sensors, is receiving increasing attention. Examples of MIP-based DDS can be found for the three main approaches developed to control the moment at which delivery should begin and/or the drug release rate, i.e. rate-programmed, activation-modulated, or feedback-regulated drug delivery. The utility of these systems for administering drugs by different routes (e.g. oral, ocular or transdermal) or trapping undesired substances under in vivo conditions is discussed. This review seeks to highlight the more remarkable advantages of the imprinting technique in the development of new efficient DDS as well as pointing out some possibilities to adapt the synthesis procedures to create systems compatible with both the relative instable drug molecules, especially of peptide nature, and the sensitive physiological tissues with which MIP-based DDS would enter into contact when administered. The prospects for future development are also analysed. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:231 / 245
页数:15
相关论文
共 110 条
[71]  
REFOJO MF, 1979, J POLYM SCI POL SYM, P227
[72]   ABSORPTION AND RELEASE OF ANTIBIOTICS BY A HYDROPHILIC IMPLANT FOR SCLERAL BUCKLING [J].
REFOJO, MF ;
LEONG, FL ;
CHAN, IM ;
TOLENTINO, FI .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 1983, 3 (01) :45-49
[73]  
Reist M, 1997, ENANTIOMER, V2, P147
[74]   POLY (N-ISOPROPYLACRYLAMIDE) - EXPERIMENT, THEORY AND APPLICATION [J].
SCHILD, HG .
PROGRESS IN POLYMER SCIENCE, 1992, 17 (02) :163-249
[75]   Imprinted polymers for selective adsorption of cholesterol from gastrointestinal fluids [J].
Sellergren, B ;
Wieschemeyer, J ;
Boos, KS ;
Seidel, D .
CHEMISTRY OF MATERIALS, 1998, 10 (12) :4037-4046
[76]   INFLUENCE OF POLYMER MORPHOLOGY ON THE ABILITY OF IMPRINTED NETWORK POLYMERS TO RESOLVE ENANTIOMERS [J].
SELLERGREN, B ;
SHEA, KJ .
JOURNAL OF CHROMATOGRAPHY, 1993, 635 (01) :31-49
[77]   RELEASE KINETICS OF PENDANT SUBSTITUTED BIOACTIVE MOLECULES FROM SWELLABLE HYDROGELS - ROLE OF CHEMICAL-REACTION AND DIFFUSIVE TRANSPORT [J].
SHAH, SS ;
KULKARNI, MG ;
MASHELKAR, RA .
JOURNAL OF MEMBRANE SCIENCE, 1990, 51 (1-2) :83-104
[78]  
SHEA KJ, 1994, TRENDS POLYM SCI, V2, P166
[79]   SPECIFIC PROTEIN ATTACHMENT TO ARTIFICIAL MEMBRANES VIA COORDINATION TO LIPID-BOUND COPPER(II) [J].
SHNEK, DR ;
PACK, DW ;
SASAKI, DY ;
ARNOLD, FH .
LANGMUIR, 1994, 10 (07) :2382-2388
[80]   Release of ketoprofen enantiomers from HPMC K100M matrices -: diffusion studies [J].
Solinís, MA ;
de la Cruz, Y ;
Hernández, RM ;
Gascón, AR ;
Calvo, B ;
Pedraz, JL .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 239 (1-2) :61-68