Comparison of M-FISH and conventional cytogenetic analysis in accelerated and acute phases of CML

被引：4

作者：

Brizard, F

Cividin, M

Villalva, C

Guilhot, F

Brizard, A

机构：

[1] Univ Poitiers Hosp, CHU Miletrie, Lab Hematol EA 2224, F-86021 Poitiers, France

[2] Univ Poitiers Hosp, Serv Oncol Hematol & Therapie Cellulaire, UPRES EA 2622, Poitiers, France

来源：

LEUKEMIA RESEARCH | 2004年 / 28卷 / 04期

关键词：

CML; accelerated phase; blast crisis; M-FISH;

D O I：

10.1016/j.leukres.2003.08.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

FISH and multicolor FISH (M-FISH) techniques have greatly enhanced the resolution of conventional cytogenetic analysis, thus enabling the identification of novel regions of rearrangement in hematological malignancies. We report on the analysis of cells from 24 chronic myelogenous leukemia (CML) patients, in either accelerated phase (14 cases) or blast crisis (10 cases) aimed at searching for previously unidentified additional abnormalities related to disease evolution. Indeed, in 6 of 24 cases (25%) M-FISH allowed a more precise description of chromosomal aberrations, the finding of cryptic rearrangements, characterization of markers, identification of additional material and a better interpretation of complex aberrations. However, new recurrent aberration did not emerge from M-FISH analysis. (C) 2003 Elsevier Ltd. All rights reserved.

引用

收藏

页码：345 / 348

页数：4

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