Synthesis of the N-((1E)-alkenyl)-(2Z,4Z)-heptadienamide side chain of salicylihalamide A and apicularens A and B

被引：69

作者：

Snider, BB ^{[1
]}

Song, FB ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem MS015, Waltham, MA 02254 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 03期

关键词：

D O I：

10.1021/ol991388+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The unstable N-((1 E)-alkenyl)-(2Z,4Z)-heptadienamide side chain of salicylihalamide A (1) and apicularens A and B (3 and 4) has been prepared in one pot by the addition of (1Z,3Z)-hexadienylcuprate, prepared in situ from EtLi, CuBr . SMe2, and acetylene, to a (1E)-alkenyl isocyanate.

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页码：407 / 408

页数：2

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