Synthetic metabolic pipelines

被引：12

作者：

DeLisa, Matthew P. ^{[1
]}

Conrado, Robert J. ^{[1
]}

机构：

[1] Cornell Univ, Sch Chem & Biomol Engn, Ithaca, NY 14850 USA

来源：

NATURE BIOTECHNOLOGY | 2009年 / 27卷 / 08期

关键词：

EVOLUTION; ENZYMES;

D O I：

10.1038/nbt0809-728

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Controlling the spatial organization of sequential metabolic enzymes may provide a general strategy for increasing the production of valuable compounds.

引用

页码：728 / 729

页数：2

共 13 条

[1]

Reversible compartmentalization of de novo purine biosynthetic complexes in living cells [J].

An, Songon ;

Kumar, Ravindra ;

Sheets, Erin D. ;

Benkovic, Stephen J. .

SCIENCE, 2008, 320 (5872) :103-106

[2]

In the light of directed evolution: Pathways of adaptive protein evolution [J].

Bloom, Jesse D. ;

Arnold, Frances H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 :9995-10000

[3]

Engineering the spatial organization of metabolic enzymes: mimicking nature's synergy [J].

Conrado, Robert J. ;

Varner, Jeffrey D. ;

DeLisa, Matthew P. .

CURRENT OPINION IN BIOTECHNOLOGY, 2008, 19 (05) :492-499

[4]

CHANNELING CAN AFFECT CONCENTRATIONS OF METABOLIC INTERMEDIATES AT CONSTANT NET FLUX - ARTIFACT OR REALITY [J].

CORNISHBOWDEN, A ;

CARDENAS, ML .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 213 (01) :87-92

[5]

Engineering synthetic signaling proteins with ultrasensitive input/output control [J].

Dueber, John E. ;

Mirsky, Ethan A. ;

Lim, Wendell A. .

NATURE BIOTECHNOLOGY, 2007, 25 (06) :660-662

[6]

Synthetic protein scaffolds provide modular control over metabolic flux [J].

Dueber, John E. ;

Wu, Gabriel C. ;

Malmirchegini, G. Reza ;

Moon, Tae Seok ;

Petzold, Christopher J. ;

Ullal, Adeeti V. ;

Prather, Kristala L. J. ;

Keasling, Jay D. .

NATURE BIOTECHNOLOGY, 2009, 27 (08) :753-U107

[7]

HYDE CC, 1988, J BIOL CHEM, V263, P17857

[8]

CONSTRUCTION OF AN ARTIFICIAL BIFUNCTIONAL ENZYME, BETA-GALACTOSIDASE GALACTOSE DEHYDROGENASE, EXHIBITING EFFICIENT GALACTOSE CHANNELING [J].

LJUNGCRANTZ, P ;

CARLSSON, H ;

MANSSON, MO ;

BUCKEL, P ;

MOSBACH, K ;

BULOW, L .

BIOCHEMISTRY, 1989, 28 (22) :8786-8792

[9]

Evolution of a Saccharomyces cerevisiae metabolic pathway in Escherichia coli [J].

Meynial Salles, Isabelle ;

Forchhammer, Nynne ;

Croux, Christian ;

Girbal, Laurence ;

Soucaille, Philippe .

METABOLIC ENGINEERING, 2007, 9 (02) :152-159

[10]

Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation [J].

Narayanaswamy, Rammohan ;

Levy, Matthew ;

Tsechansky, Mark ;

Stovall, Gwendolyn M. ;

O'Connell, Jeremy D. ;

Mirrielees, Jennifer ;

Ellington, Andrew D. ;

Marcotte, Edward M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (25) :10147-10152

← 1 2 →