A fast and highly efficient protocol for Michael addition of N-heterocycles to α,β-unsaturated compound using basic ionic liquid [bmIm]OH as catalyst and green solvent

被引：111

作者：

Xu, Jian-Ming ^{[1
]}

Qian, Chao ^{[1
]}

Liu, Bo-Kai ^{[1
]}

Wu, Qi ^{[1
]}

Lin, Xian-Fu ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

TETRAHEDRON | 2007年 / 63卷 / 04期

基金：

中国国家自然科学基金;

关键词：

ionic liquid; Michael addition; N-heterocycle; alpha; beta-unsaturated compounds;

D O I：

10.1016/j.tet.2006.11.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A fast and green protocol for the Michael addition of N-heterocycles to alpha,beta-unsaturated compounds at room temperature was developed using a basic ionic liquid, 1-methyl-3-butylimidazolium hydroxide, [bmlm]OH, as a catalyst and a reaction medium. The reactions were performed at room temperature with good yields in short reaction times (0.5-3 h). This strategy is quite general and it works with a broad range of N-heterocycles, including five-membered N-heterocycles, pyrimidines and purines. The recovered ionic liquid could be reused for several cycles with consistent activity. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：986 / 990

页数：5

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