A kinome of 2600 in the ciliate Paramecium tetraurelia

被引：12

作者：

Bemm, Felix ^{[1
]}

Schwarz, Roland ^{[1
]}

Foerster, Frank ^{[1
]}

Schultz, Joerg ^{[1
]}

机构：

[1] Bioctr, Dept Bioinformat, D-97074 Wurzburg, Germany

来源：

FEBS LETTERS | 2009年 / 583卷 / 22期

关键词：

Kinase; Genome; Sequence analysis; Domain; PROTEIN-KINASES; MEMBRANE TRAFFICKING; GENOME; DATABASE; LOCALIZATION; FOUNDATION; CALMODULIN; TREE;

D O I：

10.1016/j.febslet.2009.10.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinases play a crucial role in the regulation of cellular processes. Most eukaryotes reserve about 2.5% of their genes for protein kinases. We analysed the genome of the single-celled ciliate Paramecium tetraurelia and identified 2606 kinases, about 6.6% of its genes, representing the largest kinome to date. A gene tree combined with human kinases revealed a massive expansion of the calcium calmodulin regulated subfamily, underlining the importance of calcium in the physiology of P. tetraurelia. The kinases are embedded in only 40 domain architectures, contrasting 134 in human. This might indicate different mechanisms to achieve target specificity. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3589 / 3592

页数：4

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