c-MYC: More than just a matter of life and death

被引：931

作者：

Pelengaris, S ^{[1
]}

Khan, M

Evan, G

机构：

[1] Univ Warwick, Mol Med Res Ctr, Coventry CV4 7AL, W Midlands, England

[2] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 10期

关键词：

D O I：

10.1038/nrc904

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression. However, as established human tumours often bear multiple genetic lesions, it is difficult to determine whether c-MYC is instrumental in the initiation/progression of the tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies.

引用

页码：764 / 776

页数：13

共 134 条

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