Mitomycins syntheses: a recent update

被引：43

作者：

Andrez, Jean-Christophe ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 5卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

DNA-CROSS-LINKING; MEDIUM-SIZED RINGS; ONE-STEP SYNTHESIS; 1,2-DISUBSTITUTED MITOSENES; REDUCTIVE ACTIVATION; ENANTIOSELECTIVE SYNTHESIS; MOLECULAR CHARACTERIZATION; HETEROCYCLIC-COMPOUNDS; ANTITUMOR ANTIBIOTICS; BIOLOGICAL-ACTIVITIES;

D O I：

10.3762/bjoc.5.33

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Mitomycins are a class of very potent antibacterial and anti-cancer compounds having a broad activity against a range of tumours. They have been used in clinics since the 1960's, and the challenges represented by their total synthesis have challenged generations of chemists. Despite these chemical and medicinal features, these compounds, in racemic form, have succumbed to total synthesis only four times over the last 30 years.

引用

页数：36

共 201 条

[1]

DNA cross-linking by azinomycin B: Monte Carlo simulations in the evaluation of sequence selectivity [J].

Alcaro, S ;

Ortuso, F ;

Coleman, RS .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (04) :861-870

[2]

Allan GM, 2002, SYNLETT, P1431

[3]

MITOMYCIN ANTIBIOTICS . SYNTHETIC STUDIES .5. PREPARATION OF 7-METHOXYMITOSENE [J].

ALLEN, GR ;

POLETTO, JF ;

WEISS, MJ .

JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (09) :2897-&

[4]

Transition-metal-catalyzed addition of heteroatom-hydrogen bonds to alkynes [J].

Alonso, F ;

Beletskaya, IP ;

Yus, M .

CHEMICAL REVIEWS, 2004, 104 (06) :3079-3159

[5]

A simple, mild, catalytic, enantioselective addition of terminal acetylenes to aldehydes [J].

Anand, NK ;

Carreira, EM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (39) :9687-9688

[6]

BIOSYNTHESIS OF THE MITOMYCIN ANTIBIOTICS FROM 3-AMINO-5-HYDROXYBENZOIC ACID [J].

ANDERSON, MG ;

KIBBY, JJ ;

RICKARDS, RW ;

ROTHSCHILD, JM .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1980, (24) :1277-1278

[7]

ANDREWS PA, 1986, J AM CHEM SOC, V108, P4158, DOI 10.1021/ja00274a052

[8]

AUERBACH J, 1969, CHEM COMMUN, P991

[9]

Sharpless asymmetric dihydroxylation of 5-aryl-2-vinylfurans: Application to the synthesis of the spiroketal moiety of papulacandin D [J].

Balachari, D ;

O'Doherty, GA .

ORGANIC LETTERS, 2000, 2 (06) :863-866

[10]

Baranano D, 1997, CURR ORG CHEM, V1, P287

← 1 2 3 4 5 6 7 8 9 10 →