Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp C39217-R109-7 .1. Taxonomy of producing organism, fermentation and biological activity

被引：21

作者：

Lam, KS ^{[1
]}

Hesler, GA ^{[1
]}

Gustavson, DR ^{[1
]}

Berry, RL ^{[1
]}

Tomita, K ^{[1
]}

MacBeth, JL ^{[1
]}

Ross, J ^{[1
]}

Miller, D ^{[1
]}

Forenza, S ^{[1
]}

机构：

[1] FREDERICK CANC RES & DEV CTR,FREDERICK,MD 21702

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 09期

关键词：

D O I：

10.7164/antibiotics.49.860

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Strain C39217-R109-7 (ATCC 53791) is an actinomycete strain isolated from a soil sample collected at Puerto Viejo, Peru. It produces a new antitumor antibiotic, designated pyrrolosporin A. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Micromonospora sp. C39217-R109-7. Pyrrolosporin A shows antimicrobial activity against Gram-positive bacteria and it is weakly active against Gram-negative bacteria. Pyrrolosporin A prolongs the life span of mice inoculated with P388 leukemia cells.

引用

页码：860 / 864

页数：5

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