Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp C39217-R109-7 .2. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis

被引：30

作者：

Schroeder, DR ^{[1
]}

Colson, KL ^{[1
]}

Klohr, SE ^{[1
]}

Lee, MS ^{[1
]}

Matson, JA ^{[1
]}

Brinen, LS ^{[1
]}

Clardy, J ^{[1
]}

机构：

[1] CORNELL UNIV, BAKER LAB, DEPT CHEM, ITHACA, NY 14853 USA

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 09期

关键词：

D O I：

10.7164/antibiotics.49.865

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pyrrolosporin A (1) is a new macrolide antitumor antibiotic possessing an unusual spiro-alpha-acyltetronic acid moiety. The antibiotic was isolated from the fermentation broth of Micromonospora sp. by vacuum liquid chromatography, crystallization and reversed phase HPLC (C18). The structure was determined by a combination of NMR, MS, IR, UV, X-ray analysis and degradation studies.

引用

页码：865 / 872

页数：8

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