A novel palladium-mediated cascade reaction triggered by strain release of the cyclobutane system. A new general route to benzo- and naphthohydrindans

被引：56

作者：

Nemoto, H

Miyata, J

Yoshida, M

Raku, N

Fukumoto, K

机构：

[1] Pharmaceutical Institute, Tohoku University, Aobayama

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 22期

关键词：

D O I：

10.1021/jo971377z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel palladium-mediated cascade reaction was reported. By this procedure, the olefinic cyclobutanols 17, 24, and 31; 41; 37; and 45 afforded the benzo-and naphthohydrindans (46-49, 50-53, 54-57, and 58-61) respectively in one operation in the ratios depending on the mediators and solvents employed. This provides a novel and efficient synthesis of biologically important A-nor and C-11-alkylated steroids.

引用

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页码：7850 / 7857

页数：8

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