Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link?

被引：67

作者：

Gaffo, Angelo L. ^{[3
]}

Edwards, N. Lawrence ^{[2
]}

Saag, Kenneth G. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA

[2] Univ Florida, Div Rheumatol, Gainesville, FL 32610 USA

[3] Birmingham VA Med Ctr, Birmingham, AL 35233 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2009年 / 11卷 / 04期

关键词：

SERUM URIC-ACID; INTIMA-MEDIA THICKNESS; ALL-CAUSE MORTALITY; GLOMERULAR HYPERTENSION; LONG-TERM; INDEPENDENT PREDICTOR; OXIDATIVE STRESS; KIDNEY-FUNCTION; BLOOD-PRESSURE; RENAL-DISEASE;

D O I：

10.1186/ar2761

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

An association between high levels of serum urate and cardiovascular disease has been proposed for many decades. However, it was only recently that compelling basic science data, small clinical trials, and epidemiological studies have provided support to the idea of a true causal effect. In this review we present recently published data that study the association between hyperuricemia and selected cardiovascular diseases, with a final conclusion about the possibility of this association being causal.

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