Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link?

被引：67

作者：

Gaffo, Angelo L. ^{[3
]}

Edwards, N. Lawrence ^{[2
]}

Saag, Kenneth G. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA

[2] Univ Florida, Div Rheumatol, Gainesville, FL 32610 USA

[3] Birmingham VA Med Ctr, Birmingham, AL 35233 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2009年 / 11卷 / 04期

关键词：

SERUM URIC-ACID; INTIMA-MEDIA THICKNESS; ALL-CAUSE MORTALITY; GLOMERULAR HYPERTENSION; LONG-TERM; INDEPENDENT PREDICTOR; OXIDATIVE STRESS; KIDNEY-FUNCTION; BLOOD-PRESSURE; RENAL-DISEASE;

D O I：

10.1186/ar2761

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

An association between high levels of serum urate and cardiovascular disease has been proposed for many decades. However, it was only recently that compelling basic science data, small clinical trials, and epidemiological studies have provided support to the idea of a true causal effect. In this review we present recently published data that study the association between hyperuricemia and selected cardiovascular diseases, with a final conclusion about the possibility of this association being causal.

引用

页数：7

共 51 条

[21]

Effect of treatment of hyperuricemia with allopurinol on blood pressure, creatinine clearence, and proteinuria in patients with normal renal functions [J].

Kanbay, Mehmet ;

Ozkara, Adem ;

Selcoki, Yusuf ;

Isik, Bunyamin ;

Turgut, Faruk ;

Bavbek, Nuket ;

Uz, Ebru ;

Akcay, Ali ;

Yigitoglu, Ramazan ;

Covic, Adrian .

INTERNATIONAL UROLOGY AND NEPHROLOGY, 2007, 39 (04) :1227-1233

[22]

The impact of gout on work absence and productivity [J].

Kleinman, Nathan L. ;

Brook, Richard A. ;

Patel, Pankaj A. ;

Melkonian, Arthur K. ;

Brizee, Truman J. ;

Smeeding, James E. ;

Joseph-Ridge, Nancy .

VALUE IN HEALTH, 2007, 10 (04) :231-237

[23]

Gout is on the increase in New Zealand [J].

Klemp, P ;

Stansfield, SA ;

Castle, B ;

Robertson, MC .

ANNALS OF THE RHEUMATIC DISEASES, 1997, 56 (01) :22-26

[24]

Serum Urate Predicts Long-Term Risk of Acute Coronary Events in Women after a Transient Ischaemic Attack and Stroke [J].

Koton, Silvia ;

Howard, Sally C. ;

Warlow, Charles P. ;

Murphy, Michael F. G. ;

Rothwell, Peter M. .

CEREBROVASCULAR DISEASES, 2008, 26 (05) :517-524

[25]

Long-term cardiovascular mortality among middle-aged men with gout [J].

Krishnan, Eswar ;

Svendsen, Kenneth ;

Neaton, James D. ;

Grandits, Greg ;

Kuller, Lewis H. .

ARCHIVES OF INTERNAL MEDICINE, 2008, 168 (10) :1104-1110

[26]

Lawrence RC, 2008, ARTHRITIS RHEUM, V58, P26, DOI 10.1002/art.23176

[27]

Uric acid in the acute phase of ST elevation myocardial infarction submitted to primary PCI: Its prognostic role and relation with inflammatory markers A single center experience [J].

Lazzeri, Chiara ;

Valente, Serafina ;

Chiostri, Marco ;

Sori, Andrea ;

Bernardo, Pasquale ;

Gensini, Gian Franco .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2010, 138 (02) :206-209

[28]

Relation between serum uric acid and carotid intima-media thickness in healthy postmenopausal women [J].

Montalcini, T. ;

Gorgone, G. ;

Gazzaruso, C. ;

Sesti, G. ;

Perticone, F. ;

Pujia, A. .

INTERNAL AND EMERGENCY MEDICINE, 2007, 2 (01) :19-23

[29]

Allopurinol Use Yields Potentially Beneficial Effects on Inflammatory Indices in Those With Recent Ischemic Stroke A Randomized, Double-Blind, Placebo-Controlled Trial [J].

Muir, Scott W. ;

Harrow, Craig ;

Dawson, Jesse ;

Lees, Kennedy R. ;

Weir, Christopher J. ;

Sattar, Naveed ;

Walters, Matthew R. .

STROKE, 2008, 39 (12) :3303-3307

[30]

Associations of serum uric acid with cardiovascular events and mortality in moderate chronic kidney disease [J].

Navaneethan, Sankar D. ;

Beddhu, Srinivasan .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (04) :1260-1266

← 1 2 3 4 5 6 →