A System of Cytokines Encapsulated in ExtraCellular Vesicles

被引：283

作者：

Fitzgerald, Wendy ^{[1
]}

Freeman, Michael L. ^{[2
]}

Lederman, Michael M. ^{[2
]}

Vasilieva, Elena ^{[3
]}

Romero, Roberto ^{[4
]}

Margolis, Leonid ^{[1
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Intercellular Interact, NIH, Bethesda, MD USA

[2] Case Western Reserve Univ, Cleveland, OH 44106 USA

[3] Evdokimov Moscow Univ Med & Dent, Moscow, Russia

[4] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Neonatol Branch, NIH, Detroit, MI USA

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

IMMUNE-RESPONSES; EXOSOMES; ACTIVATION; SECRETION; CELLS; INHIBITION; BIOGENESIS; STABILITY; RELEASE; PLASMA;

D O I：

10.1038/s41598-018-27190-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Cytokines are soluble factors that mediate cell-cell communications in multicellular organisms. Recently, another system of cell-cell communication was discovered, which is mediated by extracellular vesicles (EVs). Here, we demonstrate that these two systems are not strictly separated, as many cytokines in vitro, ex vivo, and in vivo are released in EV-encapsulated forms and are capable of eliciting biological effects upon contact with sensitive cells. Association with EVs is not necessarily a property of a particular cytokine but rather of a biological system and can be changed upon system activation. EV-encapsulated cytokines were not detected by standard cytokine assays. Deciphering the regulatory mechanisms of EV-encapsulation will lead to a better understanding of cell-cell communications in health and disease.

引用

页数：11

共 34 条

[1]

Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue [J].

Arakelyan, Anush ;

Fitzgerald, Wendy ;

Zicari, Sonia ;

Vanpouille, Christophe ;

Margolis, Leonid .

SCIENTIFIC REPORTS, 2017, 7

[2]

Acid sphingomyelinase activity triggers microparticle release from glial cells [J].

Bianco, Fabio ;

Perrotta, Cristiana ;

Novellino, Luisa ;

Francolini, Maura ;

Riganti, Loredana ;

Menna, Elisabetta ;

Saglietti, Laura ;

Schuchman, Edward H. ;

Furlan, Roberto ;

Clementi, Emilio ;

Matteoli, Michela ;

Verderio, Claudia .

EMBO JOURNAL, 2009, 28 (08) :1043-1054

[3]

Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1 [J].

Biancotto, Angelique ;

Grivel, Jean-Charles ;

Iglehart, Sarah J. ;

Vanpouille, Christophe ;

Lisco, Andrea ;

Sieg, Scott F. ;

Debernardo, Robert ;

Garate, Kristen ;

Rodriguez, Benigno ;

Margolis, Leonid B. ;

Lederman, Michael M. .

BLOOD, 2007, 109 (10) :4272-4279

[4]

Cytokine receptor activation at the cell surface [J].

Broughton, Sophie E. ;

Hercus, Timothy R. ;

Lopez, Angel F. ;

Parker, Michael W. .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2012, 22 (03) :350-359

[5]

TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway [J].

Calzolari, Alessia ;

Raggi, Carla ;

Deaglio, Silvia ;

Sposi, Nadia Maria ;

Stafsnes, Marit ;

Fecchi, Katia ;

Parolini, Isabella ;

Malavasi, Fabio ;

Peschle, Cesare ;

Sargiacomo, Massimo ;

Testa, Ugo .

JOURNAL OF CELL SCIENCE, 2006, 119 (21) :4486-4498

[6]

Chemokine-Containing Exosomes Are Released from Heat-Stressed Tumor Cells via Lipid Raft-Dependent Pathway and Act as Efficient Tumor Vaccine (Publication with Expression of Concern. See vol. 211, pg. 1250, 2023) [J].

Chen, Taoyong ;

Guo, Jun ;

Yang, Mingjin ;

Zhu, Xuhui ;

Cao, Xuetao .

JOURNAL OF IMMUNOLOGY, 2011, 186 (04) :2219-2228

[7]

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles [J].

Colombo, Marina ;

Raposo, Graca ;

Thery, Clotilde .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30, 2014, 30 :255-289

[8]

Lactadherin and clearance of platelet-derived microvesicles [J].

Dasgupta, Swapan K. ;

Abdel-Monem, Hanan ;

Niravath, Polly ;

Le, Anhquyen ;

Bellera, Ricardo V. ;

Langlois, Kimberly ;

Nagata, Shigekazu ;

Rumbaut, Rolando E. ;

Thiagarajan, Perumal .

BLOOD, 2009, 113 (06) :1332-1339

[9]

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells [J].

Datta, Amrita ;

Kim, Hogyoung ;

Lal, Madhu ;

McGee, Lauren ;

Johnson, Adedoyin ;

Moustafa, Ahmed A. ;

Jones, Jennifer C. ;

Mondal, Debasis ;

Ferrer, Marc ;

Abdel-Mageed, Asim B. .

CANCER LETTERS, 2017, 408 :73-81

[10]

Human placental trophoblasts confer viral resistance to recipient cells [J].

Delorme-Axford, Elizabeth ;

Donker, Rogier B. ;

Mouillet, Jean-Francois ;

Chu, Tianjiao ;

Bayer, Avraham ;

Ouyang, Yingshi ;

Wang, Tianyi ;

Stolz, Donna B. ;

Sarkar, Saumendra N. ;

Morelli, Adrian E. ;

Sadovsky, Yoel ;

Coyne, Carolyn B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (29) :12048-12053

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