Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue

被引：86

作者：

Arakelyan, Anush ^{[1
]}

Fitzgerald, Wendy ^{[1
]}

Zicari, Sonia ^{[1
]}

Vanpouille, Christophe ^{[1
]}

Margolis, Leonid ^{[1
]}

机构：

[1] Eunice Kennedy Natl Inst Child Hlth & Human Dev, Sect Intercellular Interact, NIH, Bethesda, MD 20892 USA

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

INTEGRIN ALPHA(4)BETA(7); EXOSOMAL TRANSFER; CELLS; MICROVESICLES; ACTIVATION; SECRETION; COMPLEX; DEFINES; CGAMP; CD4;

D O I：

10.1038/s41598-017-01739-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a viral protein that mediates virus attachment and fusion to target cells, and also facilitates HIV infection in various indirect ways. Depletion of viral preparations of EVs, in particular of those that carry gp120, decreases viral infection of human lymphoid tissue ex vivo. Thus, EVs that carry Env identified in our work seem to facilitate HIV infection and therefore may constitute a new therapeutic target for antiviral strategy.

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