Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy (Publication with Expression of Concern. See vol. 365, pg. 991, 2019)

被引：168

作者：

Byrareddy, Siddappa N. ^{[1
,12
]}

Arthos, James ^{[2
]}

Cicala, Claudia ^{[2
]}

Villinger, Francois ^{[1
,3
,13
]}

Ortiz, Kristina T. ^{[1
]}

Little, Dawn ^{[1
]}

Sidell, Neil ^{[4
]}

Kane, Maureen A. ^{[5
]}

Yu, Jianshi ^{[5
]}

Jones, Jace W. ^{[5
]}

Santangelo, Philip J. ^{[6
,7
]}

Zurla, Chiara ^{[6
,7
]}

McKinnon, Lyle R. ^{[8
,14
]}

Arnold, Kelly B. ^{[9
]}

Woody, Caroline E. ^{[9
]}

Walter, Lutz ^{[10
]}

Roos, Christian ^{[10
]}

Noll, Angela ^{[10
]}

Van Ryk, Donald ^{[2
]}

Jelicic, Katija ^{[2
]}

Cimbro, Raffaello ^{[11
]}

Gumber, Sanjeev

Reid, Michelle D. ^{[1
]}

Adsay, Volkan ^{[1
]}

Amancha, Praveen K. ^{[3
]}

Mayne, Ann E. ^{[1
]}

Parslow, Tristram G. ^{[1
]}

Fauci, Anthony S.

Ansari, Aftab A. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA

[2] NIAID, Immunoregulat Lab, NIH, Bldg 10, Bethesda, MD 20892 USA

[3] Emory Univ, Div Pathol, Yerkes Natl Primate Ctr, Atlanta, GA 30329 USA

[4] Emory Univ, Sch Med, Dept Obstet & Gynecol, Atlanta, GA 30322 USA

[5] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

[6] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30680 USA

[7] Emory Univ, Atlanta, GA 30680 USA

[8] Ctr AIDS Program Res South Africa CAPRISA, Durban, South Africa

[9] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[10] German Primate Ctr, Leibniz Inst Primate Res, Primate Genet Lab, Gottingen, Germany

[11] Johns Hopkins Sch Med, Div Rheumatol, Baltimore, MD 21201 USA

[12] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA

[13] Univ Louisiana Lafayette, Off Director, New Iberia Res Ctr, New Iberia, LA 70560 USA

[14] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

来源：

SCIENCE | 2016年 / 354卷 / 6309期

关键词：

SIMIAN IMMUNODEFICIENCY VIRUS; T-CELL DEPLETION; RETINOIC ACID; LYMPHOID-TISSUE; INFECTION; HIV; REPLICATION; EXPRESSION; SIGNATURES; INNATE;

D O I：

10.1126/science.aag1276

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Antiretroviral drug therapy (ART) effectively suppresses replication of both the immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon after ART is withdrawn. SIV-infected monkeys were treated with a 90-day course of ART initiated at 5 weeks post infection followed at 9 weeks post infection by infusions of a primatized monoclonal antibody against the alpha(4)beta(7) integrin administered every 3 weeks until week 32. These animals subsequently maintained low to undetectable viral loads and normal CD4(+) T cell counts in plasma and gastrointestinal tissues for more than 9 months, even after all treatment was withdrawn. This combination therapy allows macaques to effectively control viremia and reconstitute their immune systems without a need for further therapy.

引用

页码：197 / 202

页数：6

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