Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia

被引：116

作者：

Simonsen, Anja Hviid ^{[1
]}

Herukka, Sanna-Kaisa ^{[2
,3
]}

Andreasen, Niels ^{[4
]}

Baldeiras, Ines ^{[5
]}

Bjerke, Maria ^{[6
]}

Blennow, Kaj ^{[7
]}

Engelborghs, Sebastiaan ^{[6
,8
,9
]}

Frisoni, Giovanni B. ^{[10
,11
,12
]}

Gabryelewicz, Tomasz ^{[13
]}

Galluzzi, Samantha ^{[12
]}

Handels, Ron ^{[14
]}

Kramberger, Milica G. ^{[15
]}

Kulczynska, Agnieszka ^{[16
]}

Luis Molinuevo, Jose ^{[17
,18
]}

Mroczko, Barbara ^{[16
,19
]}

Nordberg, Agneta ^{[20
]}

Oliveira, Catarina Resende ^{[5
]}

Otto, Markus ^{[21
]}

Rinne, Juha O. ^{[22
,23
]}

Rot, Uros ^{[15
]}

Saka, Esen ^{[24
]}

Soininen, Hilkka ^{[2
,3
]}

Struyfs, Hanne ^{[6
]}

Suardi, Silvia ^{[25
]}

Visser, Pieter Jelle ^{[26
,27
]}

Winblad, Bengt ^{[28
]}

Zetterberg, Henrik ^{[7
,29
]}

Waldemar, Gunhild ^{[1
]}

机构：

[1] Univ Copenhagen, Danish Dementia Res Ctr, Rigshosp, Copenhagen, Denmark

[2] Univ Eastern Finland, Dept Neurol, Kuopio, Finland

[3] Kuopio Univ Hosp, Kuopio, Finland

[4] Karolinska Univ Hosp, Dept Geriatr Med, Huddinge, Sweden

[5] Univ Coimbra, CNC IBILI Ctr Neurosci & Cell Biol, CHUC Coimbra Univ Hosp, Neurochem Lab,Fac Med,CNC, Coimbra, Portugal

[6] Univ Antwerp, Inst Born Bunge, Reference Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium

[7] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden

[8] Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Dept Neurol, Antwerp, Belgium

[9] Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Memory Clin, Antwerp, Belgium

[10] Univ Hosp, Geneva Neurosci Ctr, Geneva, Switzerland

[11] Univ Geneva, Geneva, Switzerland

[12] IRCCS Fatebenefratelli, Brescia, Italy

[13] Polish Acad Sci, Mossakowski Med Res Ctr, Dept Neurodegenerat Disorders, Warsaw, Poland

[14] Maastricht Univ, Sch Mental Hlth & Neurosci, Alzheimer Ctr Limburg, Maastricht, Netherlands

[15] Univ Med Ctr Ljubljana, Dept Neurol, Ctr Cognit Impairments, Ljubljana, Slovenia

[16] Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland

[17] IDIBAPS, Hosp Clin & Univ, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain

[18] Fundacio Pesqual Maragall, Beta Brain Res Ctr, Barcelona, Spain

[19] Univ Hosp Bialystok, Dept Biochem Diagnost, Bialystok, Poland

[20] Karolinska Inst, Translat Alzheimer Neurobiol, Ctr Alzheimer Res, Dept NVS, Huddinge, Sweden

[21] Univ Ulm, Dept Neurol, Ulm, Germany

[22] Turku Univ Hosp, Turku PET Ctr, Turku, Finland

[23] Univ Turku, Turku, Finland

[24] Hacettepe Univ Hosp, Dept Neurol, Ankara, Turkey

[25] Neurol Inst C Besta, Neuropathol Lab, Milan, Italy

[26] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[27] Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Dept Neurol, Amsterdam, Netherlands

[28] Karolinska Inst, Div Neurogeriatr, Ctr Alzheimer Res, Dept NVS, Huddinge, Sweden

[29] UCL Inst Neurol, Dept Mol Neurosci, London, England

来源：

ALZHEIMERS & DEMENTIA | 2017年 / 13卷 / 03期

基金：

芬兰科学院; 瑞典研究理事会;

关键词：

Alzheiiner's disease; Biomarkers; CSF; Diagnosis; GRADE; Recommendations; ALZHEIMERS-DISEASE DIAGNOSIS; MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID TAU; COST-EFFECTIVENESS; PHOSPHORYLATED TAU; GRADING QUALITY; GUIDELINES; MANAGEMENT; METAANALYSIS; ACCURACY;

D O I：

10.1016/j.jalz.2016.09.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebiospinal fluid (CSF) amyloid-beta(1-42), tau, and phosphorylated tau in the diagnostic evaluation of patients with dementia. The recommendations were developed by a multidisciplinary working group based on the available evidence and consensus from focused discussions for (i) identification of Alzheimer's disease (AD) as the cause of dementia, (ii) prediction of rate of decline, (iii) cost-effectiveness, and (iv) interpretation of results. The working group found sufficient evidence to support 4 recommendation to use CSF ADbiomarkers as a supplement to clinical evaluation, particularly in uncertain and atypical cases, to identify or exclude AD as the cause of dementia. Because of insufficient evidence, it was uncertain whether CSF AD bioniarkers outperform imaging biomarkers. Operational recommendations for the interpretation of ambiguous CSF biomarker results were also provided. (C) 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.

引用

页码：274 / 284

页数：11

共 40 条

[1]

Agarwal Rachna, 2011, Int J Alzheimers Dis, V2011, P503293, DOI 10.4061/2011/503293

[2]

[Anonymous], 2000, DIAGN STAT MAN TEXT

[3]

[Anonymous], ALZHEIMERS IN PRESS

[4]

[Anonymous], 1998, Health Technol Assess

[5]

Alzheimer's disease [J].

Scheltens, Philip ;

De Strooper, Bart ;

Kivipelto, Miia ;

Holstege, Henne ;

Chetelat, Gael ;

Teunissen, Charlotte E. ;

Cummings, Jeffrey ;

van der Flier, Wiesje M. .

LANCET, 2021, 397 (10284) :1577-1590

[6]

Review and Meta-Analysis of Biomarkers and Diagnostic Imaging in Alzheimer's Disease [J].

Bloudek, Lisa M. ;

Spackman, D. Eldon ;

Blankenburg, Michael ;

Sullivan, Sean D. .

JOURNAL OF ALZHEIMERS DISEASE, 2011, 26 (04) :627-645

[7]

Grading quality of evidence and strength of recommendations in clinical practice guidelines: Part 2 of 3. The GRADE approach to grading quality of evidence about diagnostic tests and strategies [J].

Brozek, J. L. ;

Akl, E. A. ;

Jaeschke, R. ;

Lang, D. M. ;

Bossuyt, P. ;

Glasziou, P. ;

Helfand, M. ;

Ueffing, E. ;

Alonso-Coello, P. ;

Meerpohl, J. ;

Phillips, B. ;

Horvath, A. R. ;

Bousquet, J. ;

Guyatt, G. H. ;

Schuenemann, H. J. .

ALLERGY, 2009, 64 (08) :1109-1116

[8]

Carter MJ, 2014, THER RECREAT J, V48, P275

[9]

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Hampel, Harald ;

Molinuevo, Jose Luis ;

Blennow, Kaj ;

Dekosky, Steven T. ;

Gauthier, Serge ;

Selkoe, Dennis ;

Bateman, Randall ;

Cappa, Stefano ;

Crutch, Sebastian ;

Engelborghs, Sebastiaan ;

Frisoni, Giovanni B. ;

Fox, Nick C. ;

Galasko, Douglas ;

Habert, Marie-Odile ;

Jicha, Gregory A. ;

Nordberg, Agneta ;

Pasquier, Florence ;

Rabinovici, Gil ;

Robert, Philippe ;

Rowe, Christopher ;

Salloway, Stephen ;

Sarazin, Marie ;

Epelbaum, Stephane ;

de Souza, Leonardo C. ;

Vellas, Bruno ;

Visser, Pieter J. ;

Schneider, Lon ;

Stern, Yaakov ;

Scheltens, Philip ;

Cummings, Jeffrey L. .

LANCET NEUROLOGY, 2014, 13 (06) :614-629

[10]

Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study [J].

Duits, Flora H. ;

Martinez-Lage, Pablo ;

Paquet, Claire ;

Engelborghs, Sebastiaan ;

Lleo, Alberto ;

Hausner, Lucrezia ;

Molinuevo, Jose L. ;

Stomrud, Erik ;

Farotti, Lucia ;

Ramakers, Inez H. G. B. ;

Tsolaki, Magda ;

Skarsgard, Constance ;

Astrand, Ragnar ;

Wallin, Anders ;

Vyhnalek, Martin ;

Holmber-Clausen, Marie ;

Forlenza, Orestes V. ;

Ghezzi, Laura ;

Ingelsson, Martin ;

Hoff, Erik I. ;

Roks, Gerwin ;

de Mendonca, Alexandre ;

Papma, Janne M. ;

Izagirre, Andrea ;

Taga, Mariko ;

Struyfs, Hanne ;

Alcolea, Daniel A. ;

Froelich, Lutz ;

Balasa, Mircea ;

Minthon, Lennart ;

Twisk, Jos W. R. ;

Persson, Staffan ;

Zetterberg, Henrik ;

van der Flier, Wiesje M. ;

Teunissen, Charlotte E. ;

Scheltens, Philip ;

Blennow, Kaj .

ALZHEIMERS & DEMENTIA, 2016, 12 (02) :154-163

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