Lipid ligand-activated transcription factors regulating lipid storage and release in human macrophages

被引：23

作者：

Chinetti-Gbaguidi, G. ^{[2
,3
,4
]}

Staels, B. ^{[1
,2
,3
,4
]}

机构：

[1] Inst Pasteur, INSERM, UR 545, F-59019 Lille, France

[2] INSERM, U545, F-59019 Lille, France

[3] Univ Lille 2, Fac Sci Pharmaceut & Biol, F-59006 Lille, France

[4] Univ Lille 2, Fac Med, F-59006 Lille, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2009年 / 1791卷 / 06期

关键词：

Transcription factor; Gene expression; Cholesterol metabolism; Atherosclerosis; LIVER-X-RECEPTOR; FOAM-CELL-FORMATION; PPAR-GAMMA LIGANDS; GENE-EXPRESSION; NUCLEAR RECEPTOR; LXR-ALPHA; CHOLESTEROL TRAFFICKING; ENDOTHELIAL-CELLS; PARTIAL AGONISM; TARGET GENE;

D O I：

10.1016/j.bbalip.2009.01.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages play a pivotal role in the development of atherosclerosis. After recruitment in the sub-endothelial space, monocytes differentiate into macrophages, accumulate lipids thus forming foam cells and secrete pro-inflammatory and matrix-degrading factors, thus playing a role in plaque development, inflammation and instability. Therefore, pharmacological modulation of macrophage functions represents an attractive strategy for the prevention and treatment of cardiovascular diseases caused by atherosclerosis. In this review, recent advances on the role of the peroxisome proliferator-activated receptor (PPAR) and liver X receptor (LXR) transcription factors in the modulation of macrophage lipid homeostasis will be discussed. (C) 2009 Elsevier B.V. All rights reserved.

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页码：486 / 493

页数：8

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