Glypican-3 A Novel Diagnostic Marker for Hepatocellular Carcinoma and More

被引：90

作者：

Kandil, Dina H. ^{[1
]}

Cooper, Kumarasen ^{[1
]}

机构：

[1] Univ Vermont, Dept Pathol, ACC, Burlington, VT 05401 USA

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2009年 / 16卷 / 02期

关键词：

glypican-3; hepatocellular carcinoma; hepatoblastoma; yolk sac tumors; squamous cell carcinoma of the lung; ONCOFETAL PROTEIN GLYPICAN-3; LUNG-TUMOR SUPPRESSOR; GERM-CELL TUMORS; WILMS-TUMOR; EXPRESSION; GPC3; LIVER; LESIONS; GROWTH; GENE;

D O I：

10.1097/PAP.0b013e3181992455

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

Glypican-3 (GPC3) is a heparan sulfate proteoglycan that plays,in important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as in oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both a-fetoprotein and hepatocyte-paraffin. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas or the ovary. The role of GPC3 in melanomas is still controversial. This article reviews the Current information oil the application of GPC3 immunostaining in surgical pathology and cytology.

引用

页码：125 / 129

页数：5

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