Enzymatically Triggered Self-Assembly of Block Copolymers

被引：139

作者：

Amir, Roey J. ^{[1
,2
,3
]}

Zhong, Sheng ^{[4
,5
]}

Pochan, Darrin J. ^{[4
,5
]}

Hawker, Craig J. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA

[2] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA

[3] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[4] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA

[5] Univ Delaware, Delaware Biotechnol Inst, Newark, DE 19716 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 39期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

MICELLES; MICELLIZATION; VESICLES; WATER; GENE;

D O I：

10.1021/ja9060917

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The polymerization of vinyl monomers with cleavable enzymatic substrates has been shown to lead to water-soluble double-hydrophilic block copolymers which, upon enzymatic activation of the diblock copolymers, become amphiphilic and undergo Self-assembly into colloidal nanostructures. The ability to change the chemical and physical characteristics of polymeric materials by an enzymatic reaction opens the way for novel and exciting applications such as enzymatic-triggered activation of surfaces and formation of nanostructures in vivo in a highly controlled manner.

引用

页码：13949 / +

页数：4

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