MapView: visualization of short reads alignment on a desktop computer

被引:58
作者
Bao, Hua [1 ,2 ]
Guo, Hui [1 ,2 ]
Wang, Jinwei [3 ]
Zhou, Renchao [1 ,2 ]
Lu, Xuemei [1 ,2 ]
Shi, Suhua [1 ,2 ]
机构
[1] Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Life Sci, Key Lab Gene Engn, Guangzhou 510275, Guangdong, Peoples R China
[3] Sichuan Univ, Sch Mfg Sci & Engn, Chengdu 610064, Peoples R China
基金
中国国家自然科学基金;
关键词
GENOME;
D O I
10.1093/bioinformatics/btp255
中图分类号
Q5 [生物化学];
学科分类号
070307 [化学生物学];
摘要
We introduce a new visual analytics tool named MapView to facilitate the representation of large-scale short reads alignment data and genetic variation analysis. MapView can handle hundreds of millions of short reads on a desktop computer with limited memory. It supports a compact alignment view for both single-end and paired end short reads, multiple navigation and zoom modes and multi-thread processing. Moreover, MapView offers automated genetic variation detection. MapView has been used in our lab and by over 10 research labs worldwide.
引用
收藏
页码:1554 / 1555
页数:2
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