Aging and age-related diseases - From endocrine therapy to target therapy

被引：45

作者：

Bao, Qi ^{[1
,3
]}

Pan, Jie ^{[2
,3
]}

Qi, Hangfei ^{[4
]}

Wang, Lu ^{[1
]}

Qian, Huan ^{[1
]}

Jiang, Fangzhen ^{[1
]}

Shao, Zheren ^{[1
]}

Xu, Fengzhi ^{[1
]}

Tao, Zhiping ^{[1
]}

Ma, Qi ^{[1
]}

Nelson, Peter ^{[5
]}

Hu, Xueqing ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Plast & Reconstruct Surg, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Dept Endocrinol & Metab, Affiliated Hosp 2, Hangzhou 310003, Zhejiang, Peoples R China

[3] Zhejiang Univ, Inst Gastroenterol, IGZJU, Hangzhou 310003, Zhejiang, Peoples R China

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[5] Univ Munich, Clin Biochem Grp, Med Klin & Poliklin 4, D-80336 Munich, Germany

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2014年 / 394卷 / 1-2期

关键词：

Aging; Age-related diseases; Endocrine; Gene; LIFE-SPAN; VENOUS THROMBOEMBOLISM; POSTMENOPAUSAL WOMEN; REPLACEMENT THERAPY; CALORIC RESTRICTION; HORMONE-THERAPY; GROWTH-HORMONE; MUTANT MICE; HEALTH; RISK;

D O I：

10.1016/j.mce.2014.07.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Aging represents an important health issue not only for the individual, but also for society in general. Burdens associated with aging are expanding as longevity increases. This has led to an enhanced focus on issues related to aging and age-related diseases. Until recently, anti-aging endocrine-therapy has been largely limited to hormone-replacement therapy (HRT) that is associated with multiple side effects, including an increased risk of cancer. This has greatly limited the application of HRT in anti-aging therapy. Recently, the focus of anti-aging research has expanded from endocrine signaling pathways to effects on regulatory gene networks. In this regard, the GHRH-GH-IGF-1/Insulin, TOR-S6K1,NAD(+)-Sirtuin, P53, Klotho and APOE pathways have been linked to processes associated with age-related diseases, including cancer, cardiovascular disease, diabetes, osteoporosis, and neurodegenerative diseases, all of which directly influence health in aging, and represent key targets in anti-aging therapy. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：115 / 118

页数：4

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