Selective inhibition of low affinity IgE receptor (CD23) processing:: P1' bicyclomethyl substituents

被引：6

作者：

Bailey, S ^{[1
]}

Bolognese, B ^{[1
]}

Faller, A ^{[1
]}

Louis-Flamberg, P ^{[1
]}

MacPherson, DT ^{[1
]}

Mayer, RJ ^{[1
]}

Marshall, LA ^{[1
]}

Milner, PH ^{[1
]}

Mistry, J ^{[1
]}

Smith, DG ^{[1
]}

Ward, JG ^{[1
]}

机构：

[1] Upper Mer, King Of Prussia, PA 19406 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(99)00552-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using a variety of alpha-hydroxy hydroxamic acid derivatives, the size and shape of the S-1' pocket for the CD23 processing metalloprotease has been explored. It has been demonstrated that a P-1' 2-naphthylmethyl group occupies most of the available space and gives excellent selectivity against fibroblast collagenase (matrix metalloproteinase-1, MMP-1) and other MMPs. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3165 / 3170

页数：6

共 7 条

[1] Selective inhibition of low affinity IgE receptor (CD23) processing [J].