Difference in target organs in carcinogenesis with a heterocyclic amine, 2-amino-3,4-dimethylimidazo[4,5-f]quinol in different strains of mice

被引：16

作者：

Fujita, H

Nagano, K

Ochiai, M

Ushijima, T

Sugimura, T

Nagao, M

Matsushima, T

机构：

[1] Natl Canc Ctr, Res Inst, Div Biochem, Chuo Ku, Tokyo 1040045, Japan

[2] Japan Bioassay Res Ctr, Kanagawa 2570015, Japan

[3] Natl Canc Ctr, Res Inst, Div Carcinogenesis, Chuo Ku, Tokyo 1040045, Japan

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1999年 / 90卷 / 11期

关键词：

MeIQ; C57BL/6N; colon adenocarcinoma; strain difference;

D O I：

10.1111/j.1349-7006.1999.tb00696.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) induces cancers in the forestomach and liver, but not in the colon, of CDF1 male and female mice, which are thought to be resistant to induction of colon cancer by 1,2-dimethylhydrazine. In this study, we examined the carcinogenicity of MeIQ in C57BL/6N female mice, which are susceptible to 1,2-dimethylhydrazine. This strain of mice developed carcinomas of the cecum, colon and liver, but not the forestomach, when given a diet containing 300 ppm of MeIQ. This fact indicates that the target organs of a chemical carcinogen change depending on the strain of a given animal species.

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页码：1203 / 1206

页数：4

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