CARCINOGENICITIES OF HETEROCYCLIC AMINES IN COOKED FOOD

被引：326

作者：

OHGAKI, H ^{[1
]}

TAKAYAMA, S ^{[1
]}

SUGIMURA, T ^{[1
]}

机构：

[1] NATL CANC CTR,RES INST,1-1 TSUKIJI 5 CHOME,CHUO KU,TOKYO 104,JAPAN

来源：

MUTATION RESEARCH | 1991年 / 259卷 / 3-4期

关键词：

HETEROCYCLIC AMINES; CARCINOGENICITY;

D O I：

10.1016/0165-1218(91)90130-E

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mutagenic heterocyclic amines in cooked foods were carcinogenic to mice, rats and/or monkeys, when they were given orally continuously. The most common target organ was the liver, but in CDF1 mice lung tumors, forestomach tumors, lymphomas/leukemias, and blood vessel tumors in the brown adipose tissues were also induced. In F344 rats, in addition to liver tumors, tumors in the Zymbal gland, skin, clitoral gland, small and large intestines, oral cavity, and mammary gland were also induced. Monkeys given IQ developed metastatic hepatocellular carcinomas.

引用

页码：399 / 410

页数：12

共 39 条

[1] CARCINOGENICITY OF 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE IN NONHUMAN-PRIMATES - INDUCTION OF TUMORS IN 3 MACAQUES
ADAMSON, RH
THORGEIRSSON, UP
SNYDERWINE, EG
THORGEIRSSON, SS
REEVES, J
DALGARD, DW
TAKAYAMA, S
SUGIMURA, T
[J]. JAPANESE JOURNAL OF CANCER RESEARCH, 1990, 81 (01): : 10 - 14
[2] GENOTOXICITY OF THE FOOD MUTAGEN 2-AMINO-3-METHYLIMIDAZO-[4,5-F]QUINOLINE (IQ) AND ANALOGS
BARNES, WS
LOVELETTE, CA
TONG, C
WILLIAMS, GM
WEISBURGER, JH
[J]. CARCINOGENESIS, 1985, 6 (03) : 441 - 444
[3] SPECIES, SEX AND ORGAN DIFFERENCES IN INDUCTION OF A CYTOCHROME-P-450 ISOZYME RESPONSIBLE FOR CARCINOGEN ACTIVATION - EFFECTS OF DIETARY HEPATOCARCINOGENIC TRYPTOPHAN PYROLYSATE COMPONENTS IN MICE AND RATS
DEGAWA, M
HISHINUMA, T
YOSHIDA, H
HASHIMOTO, Y
[J]. CARCINOGENESIS, 1987, 8 (12) : 1913 - 1918
[4] INDUCTION OF LYMPHOMA IN CDF1 MICE BY THE FOOD MUTAGEN, 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE
ESUMI, H
OHGAKI, H
KOHZEN, E
TAKAYAMA, S
SUGIMURA, T
[J]. JAPANESE JOURNAL OF CANCER RESEARCH, 1989, 80 (12): : 1176 - 1178
[5] THE ISOLATION AND IDENTIFICATION OF A NEW MUTAGEN FROM FRIED GROUND-BEEF - 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE(PHIP)
FELTON, JS
KNIZE, MG
SHEN, NH
LEWIS, PR
ANDRESEN, BD
HAPPE, J
HATCH, FT
[J]. CARCINOGENESIS, 1986, 7 (07) : 1081 - 1086
[6] TUMOR-INDUCTION IN MICE ADMINISTERED NEONATALLY WITH 2-AMINO-6-METHYLDIPYRIDO[1,2-A 3',2'-D]IMIDAZOLE OR 2-AMINO-DIPYRIDO[1,2-A 3',2'-D]IMIDAZOLE
FUJII, K
SAKAI, A
NOMOTO, K
NAKAMURA, K
[J]. CANCER LETTERS, 1988, 41 (01) : 75 - 80
[7] A CARCINOGENIC POTENCY DATABASE OF THE STANDARDIZED RESULTS OF ANIMAL BIOASSAYS
GOLD, LS
SAWYER, CB
MAGAW, R
BACKMAN, GM
DEVECIANA, M
LEVINSON, R
HOOPER, NK
HAVENDER, WR
BERNSTEIN, L
PETO, R
PIKE, MC
AMES, BN
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 1984, 58 (DEC) : 9 - 319
[8] CARCINOGENIC ACTIVITY OF 3-AMINO-1-METHYL-5H-PYRIDO [4,3-B]INDOLE (TRP-P-2), A PYROLYSIS PRODUCT OF TRYPTOPHAN
HOSAKA, S
MATSUSHIMA, T
HIRONO, I
SUGIMURA, T
[J]. CANCER LETTERS, 1981, 13 (01) : 23 - 28
[9] ISHIKAWA T, 1979, NATURALLY OCCURRING, P159
[10] POTENT NOVEL MUTAGENS PRODUCED BY BROILING FISH UNDER NORMAL CONDITIONS
KASAI, H
YAMAIZUMI, Z
WAKABAYASHI, K
NAGAO, M
SUGIMURA, T
YOKOYAMA, S
MIYAZAWA, T
SPINGARN, NE
WEISBURGER, JH
NISHIMURA, S
[J]. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1980, 56 (05): : 278 - 283

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