CARCINOGENICITIES OF HETEROCYCLIC AMINES IN COOKED FOOD

被引：326

作者：

OHGAKI, H ^{[1
]}

TAKAYAMA, S ^{[1
]}

SUGIMURA, T ^{[1
]}

机构：

[1] NATL CANC CTR,RES INST,1-1 TSUKIJI 5 CHOME,CHUO KU,TOKYO 104,JAPAN

来源：

MUTATION RESEARCH | 1991年 / 259卷 / 3-4期

关键词：

HETEROCYCLIC AMINES; CARCINOGENICITY;

D O I：

10.1016/0165-1218(91)90130-E

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mutagenic heterocyclic amines in cooked foods were carcinogenic to mice, rats and/or monkeys, when they were given orally continuously. The most common target organ was the liver, but in CDF1 mice lung tumors, forestomach tumors, lymphomas/leukemias, and blood vessel tumors in the brown adipose tissues were also induced. In F344 rats, in addition to liver tumors, tumors in the Zymbal gland, skin, clitoral gland, small and large intestines, oral cavity, and mammary gland were also induced. Monkeys given IQ developed metastatic hepatocellular carcinomas.

引用

页码：399 / 410

页数：12

共 39 条

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