Hydrogen sulphide: an endogenous stimulant of capsaicin-sensitive primary afferent neurons?

被引：8

作者：

Chahl, LA ^{[1
]}

机构：

[1] Univ Newcastle, Sch Biomed Sci, Newcastle, NSW 2308, Australia

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2004年 / 142卷 / 01期

关键词：

hydrogen sulphide; capsaicin; tachykinin;

D O I：

10.1038/sj.bjp.0705765

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hydrogen sulphide (H2S) is a gas best known for its rotten egg smell. The toxic effects of high concentrations of H2S have been extensively investigated. It is known that H2S is generated in mammalian systems, but little is known of its effects in physiological concentrations. In the present issue of this journal, Patacchini et al. present evidence that H2S stimulates capsaicin-sensitive primary afferent neurons to release tachykinins in the rat urinary bladder. The possible significance of this finding is discussed in this commentary.

引用

页码：1 / 2

页数：2

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