Prodelphinidin B-2 3,3′-di-O-gallate from Myrica rubra inhibits proliferation of A549 carcinoma cells via blocking cell cycle progression and inducing apoptosis

被引：13

作者：

Kuo, PL

Hsu, YL

Lin, TC

Lin, CC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung, Taiwan

[2] Chianan Univ Pharm & Sci, Dept Biotechnol, Tainan, Taiwan

[3] Tajen Inst Technol, Dept Pharm, Pingtung, Taiwan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 501卷 / 1-3期

关键词：

prodelphinidin B-2 3; 3 '-di-O-gallate; A549; cell; p53; Fas/APO-1; Fas ligand; apoptosis;

D O I：

10.1016/j.ejphar.2004.08.024

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

In this study, the antiproliferative activity of prodelphinidin B-2 3, 3'-di-O-gallate (PB233'OG) isolated from the bark of Myrica rubra (Myricaceae) was investigated. The results showed that PB233'OG inhibited the proliferation of A549 by blocking cell cycle progression in the G0/G1 phase and inducing apoptosis. Enzyme-linked immunosorbent assay (ELISA) showed that the G0/G1 phase arres: is due to increase the expression of p21/WAFI. An enhancement in Fas/APO-1 and its two form ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), might be responsible for the apoptotic effect induced by PB23'OG. Our study reports here for the first time that the induction of p21/WAF1 and activity of the Fas/Fas ligand apoptotic system may participate in the anti-proliferative activity of PB233'OG in A549 cells. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：41 / 48

页数：8

共 28 条

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