Neutralization of Interleukin-17 Attenuates Cholestatic Liver Fibrosis in Mice

被引：36

作者：

Zhang, S. ^{[1
]}

Huang, D. ^{[1
]}

Weng, J. ^{[1
]}

Huang, Y. ^{[1
]}

Liu, S. ^{[1
]}

Zhang, Q. ^{[1
]}

Li, N. ^{[1
]}

Wen, M. ^{[1
]}

Zhu, G. ^{[1
]}

Lin, F. ^{[1
]}

Gu, W. ^{[1
]}

机构：

[1] Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Dept Hepatopancreatobiliary Surg, Guangzhou 510180, Guangdong, Peoples R China

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2016年 / 83卷 / 02期

关键词：

REGULATORY T-CELLS; TH17; CELLS; CYTOKINES; IL-17; DISEASE; DIFFERENTIATION; STEATOHEPATITIS; FIBROBLASTS; MACROPHAGES; ACTIVATION;

D O I：

10.1111/sji.12395

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Anti-inflammation strategy is one of the proposed therapeutic approaches to hepatic fibrosis. IL-17 is critical in inflammation, but the role of IL-17 in liver fibrosis has not yet been elucidated. In this study, we investigate the role of IL-17 on bile duct ligation-induced liver injury and fibrosis in C57BL/6 mice. Animals were sacrificed at designated times, and serum and liver tissues were collected for analysis of liver function and serum IL-6, IL-1, tumour necrosis factor-alpha (TNF-) and transforming growth factor- (TGF-) levels. IL-17 blockade with anti-IL-17A mAb significantly improved liver function and decreased hepatocellular necrosis, pro-inflammatory cytokines, neutrophils and macrophages influx. Furthermore, CD3+and CD8+lymphocytes, neutrophils and macrophages were found to express IL-17, and neutrophils are the principal IL-17-producing cells after BDL-induced liver injury. These data indicated that IL-17 signal contributes to the pathogenesis of cholestatic liver injury and blocked of IL-17 could potentially benefit patients with cholestatic liver disease.

引用

页码：102 / 108

页数：7

共 30 条

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