Drug discovery from natural products

被引：133

作者：

Gullo, Vincent P.

McAlpine, James

Lam, Kin S.

Baker, Dwight

Petersen, Frank

机构：

[1] Cetek Corp, Marlborough, MA 01752 USA

[2] Ecopia Biosci, St Laurent, PQ H4S 2A1, Canada

[3] Nereus Pharmaceut Inc, San Diego, CA 92130 USA

[4] Cubist Pharmaceut Inc, Lexington, MA 02421 USA

[5] Novartis Inst Biomed Res, CH-4002 Basel, Switzerland

来源：

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | 2006年 / 33卷 / 07期

关键词：

drug discovery; natural products; drug targets; screening; secondary metabolism;

D O I：

10.1007/s10295-006-0107-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Natural product compounds are the source of numerous therapeutic agents. Recent progress to discover drugs from natural product sources has resulted in compounds that are being developed to treat cancer, resistant bacteria and viruses and immunosuppressive disorders. Many of these compounds were discovered by applying recent advances in understanding the genetics of secondary metabolism in actmomycetes, exploring the marine environment and applying new screening technologies. In many instances, the discovery a novel natural product serves as a tool to better understand targets and pathways in the disease process. This review describes recent progress in drug discovery from natural sources including several examples of compounds that inhibit novel drug targets.

引用

收藏

页码：523 / 531

页数：9

相关论文

共 29 条

[1] Capillary electrophoretic approach to screen for enzyme inhibitors in natural extracts [J].

Belenky, A ;

Hughes, D ;

Korneev, A ;

Dunayevskiy, Y .

JOURNAL OF CHROMATOGRAPHY A, 2004, 1053 (1-2) :247-251

[2] Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1 [J].

Besemer, J ;

Harant, H ;

Wang, S ;

Oberhauser, B ;

Marquardt, K ;

Foster, CA ;

Schreiner, EP ;

de Vries, JE ;

Dascher-Nadel, C ;

Lindley, IJD .

NATURE, 2005, 436 (7048) :290-293

[3] The role of natural product chemistry in drug discovery [J].

Butler, MS .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (12) :2141-2153

[4]

Butler MS, 2005, NAT PROD REP, V22, P162, DOI 10.1039/b402985m

[5] Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp. [J].

Charan, RD ;

Schlingmann, G ;

Janso, J ;

Bernan, V ;

Feng, XD ;

Carter, GT .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (08) :1431-1433

[6] A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib [J].

Chauhan, D ;

Catley, L ;

Li, GL ;

Podar, K ;

Hideshima, T ;

Velankar, M ;

Mitsiades, C ;

Mitsiades, N ;

Yasui, H ;

Letai, A ;

Ovaa, H ;

Berkers, C ;

Nicholson, B ;

Chao, TH ;

Neuteboom, STC ;

Richardson, P ;

Palladino, MA ;

Anderson, KC .

CANCER CELL, 2005, 8 (05) :407-419

[7] Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation [J].

Cheng, ZL ;

Jiang, Y ;

Mandon, EC ;

Gilmore, R .

JOURNAL OF CELL BIOLOGY, 2005, 168 (01) :67-77

[8] FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors [J].

Chiba, K .

PHARMACOLOGY & THERAPEUTICS, 2005, 108 (03) :308-319

[9] Salinosporamide A:: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora [J].

Feling, RH ;

Buchanan, GO ;

Mincer, TJ ;

Kauffman, CA ;

Jensen, PR ;

Fenical, W .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (03) :355-+

[10] A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum [J].

Garrison, JL ;

Kunkel, EJ ;

Hegde, RS ;

Taunton, J .

NATURE, 2005, 436 (7048) :285-289