The functional role of long non-coding RNAs and epigenetics

被引：269

作者：

Cao, Jinneng ^{[1
]}

机构：

[1] Fuyong Peoples Hosp, Dept Resp Med, Shenzhen 518103, Guangdong, Peoples R China

来源：

BIOLOGICAL PROCEDURES ONLINE | 2014年 / 16卷

关键词：

lncRNAs; Epigenetics; Transcriptional repression; Chromatin; TUMOR-SUPPRESSOR MICRORNAS; CEREBRAL-ARTERY OCCLUSION; DNA METHYLATION; GENE-EXPRESSION; MESSENGER-RNA; CHROMATIN MODIFICATIONS; IMPRINTED GENE; EMERGING ROLE; CELL; GENOME;

D O I：

10.1186/1480-9222-16-11

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Long non-coding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. The post-transcriptional regulation is influenced by these lncRNAs by interfering with the microRNA pathways, involving in diverse cellular processes. The regulation of gene expression by lncRNAs at the epigenetic level, transcriptional and post-transcriptional level have been well known and widely studied. Recent recognition that lncRNAs make effects in many biological and pathological processes such as stem cell pluripotency, neurogenesis, oncogenesis and etc. This review will focus on the functional roles of lncRNAs in epigenetics and related research progress will be summarized.

引用

页数：13

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