Elongation by RNA polymerase II: the short and long of it

被引：544

作者：

Sim, RJ

Belotserkovskaya, R

Reinberg, D ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Howard Hughes Med Inst, Piscataway, NJ 08854 USA

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Biochem, Div Nucle Acids Enzymol, Piscataway, NJ 08854 USA

来源：

GENES & DEVELOPMENT | 2004年 / 18卷 / 20期

关键词：

elongation; transcription; RNA polymerase II; chromatin CTD;

D O I：

10.1101/gad.1235904

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Appreciable advances into the process of transcript elongation by RNA polymerase II (RNAP II) have identified this stage as a dynamic and highly regulated step of the transcription cycle. Here, we discuss the many factors that regulate the elongation stage of transcription. Our discussion includes the classical elongation factors that modulate the activity of RNAP II, and the more recently identified factors that facilitate elongation on chromatin templates. Additionally, we discuss the factors that associate with RNAP II, but do not modulate its catalytic activity. Elongation is highlighted as a central process that coordinates multiple stages in mRNA biogenesis and maturation.

引用

收藏

页码：2437 / 2468

页数：32

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