The Current STATus of lymphocyte signaling: new roles for old players

被引：112

作者：

Adamson, Adewole S. ^{[1
,2
]}

Collins, Kalonji ^{[1
]}

Laurence, Arian ^{[1
]}

O'Shea, John J. ^{[1
]}

机构：

[1] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA

[2] Harvard Mit Div Hlth Sci & Technol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 02期

关键词：

HYPER-IGE SYNDROME; ROR-GAMMA-T; ARYL-HYDROCARBON RECEPTOR; T(H)17 CELL-DIFFERENTIATION; INFLAMMATORY-BOWEL-DISEASE; GENOME-WIDE ASSOCIATION; TGF-BETA; RHEUMATOID-ARTHRITIS; INTERFERON-GAMMA; CROHNS-DISEASE;

D O I：

10.1016/j.coi.2009.03.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Recently, our understanding of helper/effector T cell differentiation has changed significantly. New subsets of T cells continue to be recognized, including Th17, Treg, and Th9 cells. In addition, the signaling pathways that contribute to their generation continue to be refined. It has become clear that STAT family proteins play a major role in these 'new' T cell fates, along with their critical role in more classical fates. Importantly, genetic studies implicate STATs in autoimmune and primary immunodeficiency diseases in humans. Focusing on how STATs work in concert with other transcription factors will hopefully provide a better mechanistic understanding of the pathogenesis of various autoimmune diseases.

引用

页码：161 / 166

页数：6

共 50 条

[1]

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].

Aujla, Shean J. ;

Chan, Yvonne R. ;

Zheng, Mingquan ;

Fei, Mingjian ;

Askew, David J. ;

Pociask, Derek A. ;

Reinhart, Todd A. ;

McAllister, Florencia ;

Edeal, Jennifer ;

Gaus, Kristi ;

Husain, Shahid ;

Kreindler, James L. ;

Dubin, Patricia J. ;

Pilewski, Joseph M. ;

Myerburg, Mike M. ;

Mason, Carol A. ;

Iwakura, Yoichiro ;

Kolls, Jay K. .

NATURE MEDICINE, 2008, 14 (03) :275-281

[2]

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].

Barrett, Jeffrey C. ;

Hansoul, Sarah ;

Nicolae, Dan L. ;

Cho, Judy H. ;

Duerr, Richard H. ;

Rioux, John D. ;

Brant, Steven R. ;

Silverberg, Mark S. ;

Taylor, Kent D. ;

Barmada, M. Michael ;

Bitton, Alain ;

Dassopoulos, Themistocles ;

Datta, Lisa Wu ;

Green, Todd ;

Griffiths, Anne M. ;

Kistner, Emily O. ;

Murtha, Michael T. ;

Regueiro, Miguel D. ;

Rotter, Jerome I. ;

Schumm, L. Philip ;

Steinhart, A. Hillary ;

Targan, Stephan R. ;

Xavier, Ramnik J. ;

Libioulle, Cecile ;

Sandor, Cynthia ;

Lathrop, Mark ;

Belaiche, Jacques ;

Dewit, Olivier ;

Gut, Ivo ;

Heath, Simon ;

Laukens, Debby ;

Mni, Myriam ;

Rutgeerts, Paul ;

Van Gossum, Andre ;

Zelenika, Diana ;

Franchimont, Denis ;

Hugot, Jean-Pierre ;

de Vos, Martine ;

Vermeire, Severine ;

Louis, Edouard ;

Cardon, Lon R. ;

Anderson, Carl A. ;

Drummond, Hazel ;

Nimmo, Elaine ;

Ahmad, Tariq ;

Prescott, Natalie J. ;

Onnie, Clive M. ;

Fisher, Sheila A. ;

Marchini, Jonathan ;

Ghori, Jilur .

NATURE GENETICS, 2008, 40 (08) :955-962

[3]

High-resolution profiling of histone methylations in the human genome [J].

Barski, Artern ;

Cuddapah, Suresh ;

Cui, Kairong ;

Roh, Tae-Young ;

Schones, Dustin E. ;

Wang, Zhibin ;

Wei, Gang ;

Chepelev, Iouri ;

Zhao, Keji .

CELL, 2007, 129 (04) :823-837

[4]

Induction and effector functions of TH17 cells [J].

Bettelli, Estelle ;

Korn, Thomas ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE, 2008, 453 (7198) :1051-1057

[5]

The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 [J].

Bruestle, Anne ;

Heink, Sylvia ;

Huber, Magdalena ;

Rosenplaenter, Christine ;

Stadelmann, Christine ;

Yu, Philipp ;

Arpaia, Enrico ;

Mak, Tak W. ;

Kamradt, Thomas ;

Lohoff, Michael .

NATURE IMMUNOLOGY, 2007, 8 (09) :958-966

[6]

IL-2 receptor β-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells [J].

Burchill, Matthew A. ;

Yang, Jianying ;

Vogtenhuber, Christine ;

Blazar, Bruce R. ;

Farrar, Michael A. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (01) :280-290

[7]

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells [J].

Chen, Zhi ;

Laurence, Arian ;

Kanno, Yuka ;

Pacher-Zavisin, Margit ;

Zhu, Bing-Mei ;

Tato, Cristina ;

Yoshimura, Akihiko ;

Hennighausen, Lothar ;

O'Shea, John J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (21) :8137-8142

[8]

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3- effector T cells [J].

Dardalhon, Valerie ;

Awasthi, Amit ;

Kwon, Hyoung ;

Galileos, George ;

Gao, Wenda ;

Sobel, Raymond A. ;

Mitsdoerffer, Meike ;

Strom, Terry B. ;

Elyaman, Wassim ;

Ho, I-Cheng ;

Khoury, Samia ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE IMMUNOLOGY, 2008, 9 (12) :1347-1355

[9]

Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells [J].

de Beaucoudrey, Ludovic ;

Puel, Anne ;

Filipe-Santos, Orchidee ;

Cobat, Aurelie ;

Ghandil, Pegah ;

Chrabieh, Maya ;

Feinberg, Jacqueline ;

von Bernuth, Horst ;

Samarina, Arina ;

Janniere, Lucile ;

Fieschi, Claire ;

Stephan, Jean-Louis ;

Boileau, Catherine ;

Lyonnet, Stanislas ;

Jondeau, Guillaume ;

Cormier-Daire, Valerie ;

Le Merrer, Martine ;

Hoarau, Cyrille ;

Lebranchu, Yvon ;

Lortholary, Olivier ;

Chandesris, Marie-Olivia ;

Tron, Francois ;

Gambineri, Eleonora ;

Bianchi, Lucia ;

Rodriguez-Gallego, Carlos ;

Zitnik, Simona E. ;

Vasconcelos, Julia ;

Guedes, Margarida ;

Vitor, Artur Bonito ;

Marodi, Laszlo ;

Chapel, Helen ;

Reid, Brenda ;

Roifman, Chaim ;

Nadal, David ;

Reichenbach, Janine ;

Caragol, Isabel ;

Garty, Ben-Zion ;

Dogu, Figen ;

Camcioglu, Yildiz ;

Gulle, Sanyie ;

Sanal, Ozden ;

Fischer, Alain ;

Abel, Laurent ;

Stockinger, Birgitta ;

Picard, Capucine ;

Casanova, Jean-Laurent .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (07) :1543-1550

[10]

TH 17 cells in development:: an updated view of their molecular identity and genetic programming [J].

Dong, Chen .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (05) :337-348

← 1 2 3 4 5 →