Analytical microdevices for mass spectrometry

被引：104

作者：

Oleschuk, RD ^{[1
]}

Harrison, DJ ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2000年 / 19卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

microfluidics; mass spectrometry; electrospray ionization; proteomics; micro total analysis systems; chip-mass spectrometry;

D O I：

10.1016/S0165-9936(00)00013-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The seemingly unlikely marriage between large mass spectrometers and small microchips is actually a good one. Microfluidic devices have been coupled to mass spectrometers using electrospray ionization interfaces. Different interface designs and various integrated protein preparation and preconcentration procedures are reviewed. The potential role of chip-mass spectrometry in proteomics and drug discovery is also discussed. (C)2000 Elsevier Science B.V. All rights reserved.

引用

页码：379 / 388

页数：10

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