Phe and asn side chains in DNA double strands

被引：5

作者：

Diederichsen, U ^{[1
]}

Biro, CM

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Tech Univ Munich, Inst Organ Chem & Biochem, D-85747 Garching, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(00)00231-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The contribution of amino acid side chains to the recognition of DNA by peptides or proteins is evaluated by substituting single nucleobases of a DNA double strand by amino acid side chains. C-nucleosides with the side chains of phenylalanine and asparagine were synthesized and incorporated in DNA. This modification should allow to keep the double strand conformation. Hydrogen bonds, pi-pi-interactions and solvation have an influence on the double strand stability. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1417 / 1420

页数：4

共 26 条

[1] Synthesis of novel C-nucleosides with potential applications in combinatorial and parallel synthesis [J].

Adlington, RM ;

Baldwin, JE ;

Pritchard, GJ ;

Spencer, KC .

TETRAHEDRON LETTERS, 2000, 41 (04) :575-578

[2]

BIRO MC, 1999, THESIS TU MUNCHEN

[3] Incorporation and characterization of abasic and phenyl residues in peptide nucleic acids [J].

Challa, H ;

Woski, SA .

TETRAHEDRON LETTERS, 1999, 40 (48) :8333-8336

[4] AN EFFICIENT METHOD FOR THE SYNTHESIS OF AROMATIC C-NUCLEOSIDES [J].

CHAUDHURI, NC ;

KOOL, ET .

TETRAHEDRON LETTERS, 1995, 36 (11) :1795-1798

[5]

Chaudhuri NC, 1997, SYNLETT, P341

[6] Pairing properties of alanyl peptide nucleic acids containing an amino acid backbone with alternating configuration [J].

Diederichsen, U .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (04) :445-448

[7] Alanyl PNA: Evidence for linear band structures based on guanine-cytosine base pairs [J].

Diederichsen, U .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (17) :1886-1889

[8]

Diederichsen U, 1998, ANGEW CHEM INT EDIT, V37, P1655, DOI 10.1002/(SICI)1521-3773(19980703)37:12<1655::AID-ANIE1655>3.0.CO

[9]

2-2

[10]

Diederichsen U, 1999, SYNLETT, P917

← 1 2 3 →