Synthesis of the C(1)-C(16) fragment of bryostatins

被引：31

作者：

O'Brien, M ^{[1
]}

Taylor, NH ^{[1
]}

Thomas, EJ ^{[1
]}

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(02)01054-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of the C(l)-C(16) fragment 43 of the bryostatins is reported which features a stereoselective equivalent of an 'ene' reaction between the allylsilane 35 and the alkynone 33 and the stereoselective Conjugate addition-cyclisation of the dienyl ketone 36 to give the acetal 39 after acetalisation. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：5491 / 5494

页数：4

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