Finding distal regulatory elements in the human genome

被引：187

作者：

Heintzman, Nathaniel D. ^{[3
]}

Ren, Bing ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Ludwig Inst Canc Res, Sch Med, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Jacobs Sch Engn, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 06期

关键词：

DNA-BINDING SPECIFICITIES; TRANSCRIPTION FACTORS; ENHANCER-BLOCKING; GENE-REGULATION; CORE PROMOTER; CTCF-BINDING; PROTEIN CTCF; CONFORMATION; INSULATORS; ACTIVATION;

D O I：

10.1016/j.gde.2009.09.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transcriptional regulation of human genes depends not only on promoters and nearby cis-regulatory elements, but also on distal regulatory elements such as enhancers, insulators, locus control regions, and silencing elements, which are often located far away from the genes they control. Our knowledge of human distal regulatory elements is very limited, but the last several years have seen rapid progress in the development of strategies to identify these long-range regulatory sequences throughout the human genome. Here, we review these advances, focusing on two important classes of distal regulatory sequences - enhancers and insulators.

引用

页码：541 / 549

页数：9

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