Cryptic transmission of SARS-CoV-2 in Washington state

被引：130

作者：

Bedford, Trevor ^{[1
,2
,3
]}

Greninger, Alexander L. ^{[1
,4
]}

Roychoudhury, Pavitra ^{[1
,4
]}

Starita, Lea M. ^{[2
,3
]}

Famulare, Michael ^{[5
]}

Huang, Meei-Li ^{[1
,4
]}

Nalla, Arun ^{[4
]}

Pepper, Gregory ^{[4
]}

Reinhardt, Adam ^{[4
]}

Xie, Hong ^{[4
]}

Shrestha, Lasata ^{[4
]}

Nguyen, Truong N. ^{[4
]}

Adler, Amanda ^{[6
]}

Brandstetter, Elisabeth ^{[7
]}

Cho, Shari ^{[2
,3
]}

Giroux, Danielle ^{[3
]}

Han, Peter D. ^{[2
,3
]}

Fay, Kairsten ^{[1
]}

Frazar, Chris D. ^{[3
]}

Ilcisin, Misja ^{[1
]}

Lacombe, Kirsten ^{[6
]}

Lee, Jover ^{[2
,3
]}

Kiavand, Anahita ^{[3
]}

Richardson, Matthew ^{[1
]}

Sibley, Thomas R. ^{[2
,3
]}

Truong, Melissa ^{[2
,3
]}

Wolf, Caitlin R. ^{[2
,3
]}

Nickerson, Deborah A. ^{[2
,3
]}

Rieder, Mark J. ^{[2
,3
]}

Englund, Janet A. ^{[2
,6
,8
]}

Hadfield, James ^{[1
]}

Hodcroft, Emma B. ^{[9
,10
]}

Huddleston, John ^{[1
,11
]}

Moncla, Louise H. ^{[1
]}

Mueller, Nicola F. ^{[1
]}

Neher, Richard A. ^{[9
,10
]}

Deng, Xianding ^{[12
]}

Gu, Wei ^{[12
]}

Federman, Scot ^{[12
]}

Chiu, Charles ^{[12
]}

Duchin, Jeffrey S. ^{[7
,13
]}

Gautom, Romesh ^{[14
]}

Melly, Geoff ^{[14
]}

Hiatt, Brian ^{[14
]}

Dykema, Philip ^{[14
]}

Lindquist, Scott ^{[14
]}

Queen, Krista ^{[15
]}

Tao, Ying ^{[15
]}

Uehara, Anna ^{[15
]}

Tong, Suxiang ^{[15
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA

[2] Brotman Baty Inst Precis Med, Seattle, WA 98104 USA

[3] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

[4] Univ Washington, Dept Lab Med & Pathol, Seattle, WA 98195 USA

[5] Inst Dis Modeling, Bellevue, WA USA

[6] Seattle Childrens Hosp, Div Infect Dis, Seattle, WA USA

[7] Univ Washington, Div Allergy & Infect Dis, Dept Med, Seattle, WA 98195 USA

[8] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

[9] Univ Basel, Biozentrum, Basel, Switzerland

[10] Swiss Inst Bioinformat, Lausanne, Switzerland

[11] Univ Washington, Mol & Cellular Biol Program, Seattle, WA 98195 USA

[12] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA

[13] Publ Hlth Seattle & King Cty, Seattle, WA USA

[14] Washington State Dept Hlth, Shoreline, WA USA

[15] Ctr Dis Control & Prevent, Div Viral Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

[16] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Off Adv Mol Detect, Atlanta, GA USA

[17] Howard Hughes Med Inst, Seattle, WA USA

来源：

SCIENCE | 2020年 / 370卷 / 6516期

关键词：

CORONAVIRUS;

D O I：

10.1126/science.abc0523

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

After its emergence in Wuhan, China, in late November or early December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus rapidly spread globally. Genome sequencing of SARS-CoV-2 allows the reconstruction of its transmission history, although this is contingent on sampling. We analyzed 453 SARS-CoV-2 genomes collected between 20 February and 15 March 2020 from infected patients in Washington state in the United States. We find that most SARS-CoV-2 infections sampled during this time derive from a single introduction in late January or early February 2020, which subsequently spread locally before active community surveillance was implemented.

引用

页码：571 / +

页数：5

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