Quantitative effects of palivizumab and donor-derived T cells on chronic respiratory syncytial virus infection, lung disease, and fusion glycoprotein amino acid sequences in a patient before and after bone marrow transplantation

被引：37

作者：

El Saleeby, CM

Suzich, J

Conley, ME

DeVincenzo, JP

机构：

[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[3] Univ Tennessee, Dept Pediat, Memphis, TN USA

[4] Childrens Fdn Res Ctr, Memphis, TN USA

[5] St Jude Childrens Res Hosp, LeBonheur Childrens Med Ctr, Memphis, TN 38101 USA

[6] MedImmune Inc, Gaithersburg, MD 20878 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2004年 / 39卷 / 02期

关键词：

D O I：

10.1086/421779

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A patient with respiratory syncytial virus (RSV) infection and severe combined immunodeficiency was studied during a 3-month period of bone marrow transplantation and palivizumab infusion. No RSV isolates with palivizumab escape mutations were identified. Donor lymphocytes, including CD8 cells, appeared to markedly reduce the RSV load but increased the pulmonary symptoms. Immunosuppressive therapy ameliorated lung disease but allowed the RSV load to rebound.

引用

页码：E17 / E20

页数：4

共 15 条

[11] Treatment of respiratory syncytial virus bronchiolitis and pneumonia in a cotton rat model with systemically administered monoclonal antibody (palivizumab) and glucocorticosteroid [J].