Reproductive factors and lung cancer risk among women in the Singapore Breast Cancer Screening Project

被引:23
作者
Tan, Hui Shan [1 ,2 ]
Tan, Min-Han [1 ,2 ,3 ]
Chow, Khuan Yew [4 ]
Chay, Wen Yee [2 ]
Lim, Wei-Yen [1 ]
机构
[1] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore
[2] Natl Canc Ctr Singapore, Div Med Oncol, Singapore, Singapore
[3] Inst Bioengn & Nanotechnol, Singapore, Singapore
[4] Natl Registry Dis Off, Singapore, Singapore
关键词
Cohort study; Lung neoplasms; Reproductive history; Parity; Menarche; HORMONE REPLACEMENT THERAPY; ESTROGEN-RECEPTOR-BETA; POSTMENOPAUSAL WOMEN; CHINESE WOMEN; NEVER-SMOKERS; SMOKING; ADENOCARCINOMA; ASSOCIATION; EXPRESSION; MENARCHE;
D O I
10.1016/j.lungcan.2015.10.003
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Objectives: A growing body of literature suggests that female hormones play a role in lung cancer risk. Our study aims to examine the relationship between reproductive factors and lung cancer incidence in a large prospectively enrolled cohort in Singapore. Materials and Methods: Multivariate Cox proportional hazard regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of lung cancer for each exposure, adjusting for smoking, age at entry, ethnicity and body mass index. Results: Among 28,222 women aged 50-64 years enrolled in the Singapore Breast Cancer Screening Project from October 1994 to February 1997, we identified 311 incident lung cancer cases (253 in non-smokers) over an average of 15.8 years of follow-up to 31 December 2011. Higher parity was associated with decreased lung cancer risk. Compared with nulliparous women, those with 1-2, 3-4, and >= 5 deliveries had a hazard ratio (HR) of 0.56, 0.55 and 0.45, respectively (P-trend <0.01). This association was observed in both smokers and non-smokers, and in both adenocarcinomas and non-adenocarcinomas. Reproductive period, breastfeeding, oral contraceptive and hormone replacement therapy use did not seem to influence the risk of getting lung cancer. Conclusion: Our findings add to the existing evidence that parous women have a lower lung cancer risk than nulliparous women. (c) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:499 / 508
页数:10
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