Synthesis of non-natural C2-homo-ceramide and its apoptotic activity against HL-60 cells

被引：16

作者：

Shikata, K ^{[1
]}

Niiro, H ^{[1
]}

Azuma, H ^{[1
]}

Tachibana, T ^{[1
]}

Ogino, K ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Engn, Dept Appl & Bioappl Chem, Sumiyoshi Ku, Osaka 5588585, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(02)01026-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Non-natural ceramide analogues, C2-homo-ceramide and C2-homo-dihydroceramide, were prepared from L-aspartic acid via L-homo-serine. The apoptotic activities of the synthesized ceramide analogues were examined in HL-60 human leukemia cells. C2-homo- and C2-bishomo-ceramide indicate low but considerable apoptotic activities in comparison with C2-ceramide. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：613 / 616

页数：4