Cellular landscaping of exosomal miRNAs in cancer metastasis: From chemoresistance to prognostic markers

被引：8

作者：

Bhattacharjee, Rahul ^{[1
]}

Mitra, Priya ^{[2
]}

Gupta, Nitin ^{[3
]}

Sharma, Sony ^{[4
]}

Singh, Vipendra Kumar ^{[5
]}

Mukerjee, Nobendu ^{[6
,7
]}

Dhasmana, Archna ^{[8
]}

Gundamaraju, Rohit ^{[9
]}

机构：

[1] Tel Aviv Univ, Sackler Sch Med, Dept Cell & Dev Biol, IL-69978 Tel Aviv, Israel

[2] Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India

[3] Sanjay Gandhi Postgrad Inst Med Sci, Ctr Biomed Res, Lucknow 226014, India

[4] Natl Inst Mental Hlth & Neurosci, Dept Neurovirol, Bengaluru 560029, Karnataka, India

[5] Indian Inst Technol Mandi, Sch Basic Sci, Mandi 175005, Himachal Prades, India

[6] Ramakrishna Mission Vivekananda Centenary Coll, Dept Microbiol, Kolkata 700118, West Bengal, India

[7] Novel Global Community Educ Fdn, Dept Hlth Sci, Hebersham, NSW, Australia

[8] Swami Rama Himalayan Univ, Himalayan Sch Biosci, Jollygrant Dehradun, Dehra Dun 248016, Uttarakhand, India

[9] Univ Tasmania, Sch Hlth Sci, ER Stress & Mucosal Immunol Lab, Launceston, Tas 7248, Australia

来源：

ADVANCES IN CANCER BIOLOGY-METASTASIS | 2022年 / 5卷

关键词：

miRNAs; Metastasis; Chemoresistance; Prognosis; Extracellular vesicles; Immunotherapy; EPITHELIAL-MESENCHYMAL TRANSITIONS; E-CADHERIN; DENDRITIC CELLS; STEM-CELLS; EXTRACELLULAR VESICLES; CLINICAL-RELEVANCE; MICRORNA LEVELS; NICHE FORMATION; BODY-FLUIDS; TUMOR;

D O I：

10.1016/j.adcanc.2022.100050

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Exosomes are cargos facilitating the transport of miRNAs across cancer cells. Exosomal miRNA has been an area of interest in recent times due to their triple role in cancer proliferation. The current review discusses the triple role of exosomal miRNAs and proposes its application in diagnosis as a prognostic marker. Exosomal miRNAs are miRNAs found inside the exosomal structure of 30-150 nm of an extracellular vesicle. The synthesis and biogenesis of these exosomal miRNA involve an endosomal sorting complex required for transport which releases miRNAs and relevant proteins to cause tumor heterogeneity, drug resistance, and cancer metastasis. Herein, we have highlighted the role of exosomal miRNAs in both drug resistance and cancer metastasis. Additionally, we have elucidated the impact of exosomal miRNAs upon host immunity, which will provide us with the idea of host immune rejection. Furthermore, we have elaborated the clinical importance of exosomal miRNAs as a prognostic marker.

引用

页数：12

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