Biogenesis of secretory granules

被引：70

作者：

Borgonovo, Barbara

Ouwendijk, Joke

Solimena, Michele

机构：

[1] Dresden Univ Technol, Carl Gustav Carus Med Sch, D-01307 Dresden, Germany

[2] Dresden Univ Technol, Carl Gustav Carus Med Sch, Med Clin 3, D-01307 Dresden, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2006年 / 18卷 / 04期

关键词：

D O I：

10.1016/j.ceb.2006.06.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Secretory granules of neuroendocrine cells store and release peptide hormones and neuropeptides in response to various stimuli. Generation of granules from the Golgi complex involves the aggregation of cargo proteins and their sorting from non-regulated secretory molecules. Recent findings on knockout mice lacking individual granule constituents have challenged the hypothesis that an 'essential' protein for the assembly of these organelles exists, while studies on polypyrimidine tract-binding protein and ICA512/IA-2 have provided insight into the mechanisms for adjusting granule production in relation to stimulation and secretory activity.

引用

收藏

页码：365 / 370

页数：6

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