Non-genetic heterogeneity of cells in development: more than just noise

被引:372
作者
Huang, Sui [1 ]
机构
[1] Univ Calgary, Inst Biocomplex & Informat, Calgary, AB T3A 0Y1, Canada
来源
DEVELOPMENT | 2009年 / 136卷 / 23期
基金
美国国家卫生研究院;
关键词
STOCHASTIC GENE-EXPRESSION; STEM-CELLS; DIFFERENTIATION; DYNAMICS; VARIABILITY; ROBUSTNESS; PLASTICITY; EVOLUTION; NETWORK; CHANCE;
D O I
10.1242/dev.035139
中图分类号
Q [生物科学];
学科分类号
090105 [作物生产系统与生态工程];
摘要
Cell-to-cell variability of gene expression in clonal populations of mammalian cells is ubiquitous. However, because molecular biologists habitually assume uniformity of the cell populations that serve as starting material for experimental analysis, attention to such non-genetic heterogeneity has been scant. As awareness of, and interest in, understanding its biological significance increases, this Primer attempts to clarify the confusing terminologies used in an emerging field that often conflates heterogeneity with noise, and provides a qualitative introduction to the fundamental dynamic principles that underlie heterogeneity. It thus aims to present a useful conceptual framework to organize, analyze and communicate observations made at the resolution of individual cells that indicate that heterogeneity of cell populations plays a biological role, such as in multipotency and cell fate decision.
引用
收藏
页码:3853 / 3862
页数:10
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