Recovery of injured adrenal medulla by differentiation of pre-existing undifferentiated chromaffin cells

被引：5

作者：

Pan, CC

Pan, IJ ^{[1
]}

Yamamoto, Y

Chen, HHC

Hayashi, Y

机构：

[1] Nihon Univ, Coll Bioresource Sci, Lab Vet Epizootiol, Fujisawa, Kanagawa 2528510, Japan

[2] Univ Tokyo, Fac Agr, Dept Vet Anat, Bunkyo Ku, Tokyo 113, Japan

[3] Res Inst Anim Sci Biochem & Toxicol, Sagamihara, Kanagawa, Japan

[4] Natl Sci Council, Natl Lab Anim Breeding & Res Ctr, Taipei, Taiwan

来源：

TOXICOLOGIC PATHOLOGY | 2002年 / 30卷 / 02期

关键词：

adrenal medulla; adrenal cortex; chromaffin cells; pheochromoblast; Schwann cell; salinomycin;

D O I：

10.1080/019262302753559498

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

We described previous that the adrenal medulla recovers rapidly from the injuries due to salinomycin. In the present study we found the recovery to be apparently due to differentiation of pre-existing, primitive undifferentiated, chromaffin cells, rather than mitosis, as evidenced by lack of incorporation of 5-bromo-2-deoxyuridine in the differentiating and/or differentiated chromaffin cells. Electron-dense, striated fibrils observed within the necrotic cells and in the extracellular space were presumed to be intermediate degradation products. Schwann cells actively functioned as phagocytes in this study, and seemed to indirectly stimulate the differentiation of undifferentiated chromaffin cells.

引用

页码：165 / 172

页数：8

共 16 条

[1] Prompt recovery of damaged adrenal medullae induced by salinomycin [J].